Xu Wang Hong, Dai Qi, Xiang Yong Bing, Long Ji Rong, Ruan Zhi Xian, Cheng Jia Rong, Zheng Wei, Shu Xiao Ou
Department of Epidemiology, Shanghai Cancer Institute and Cancer Institute of Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Am J Epidemiol. 2007 Dec 15;166(12):1420-30. doi: 10.1093/aje/kwm242. Epub 2007 Sep 7.
Certain polyphenols inhibit the activity of aromatase, a critical enzyme in estrogen synthesis that is coded by the CYP19A1 gene. Consumption of polyphenol-rich foods and beverages, thus, may interact with CYP19A1 genetic polymorphisms in the development of endometrial cancer. The authors tested this hypothesis in the Shanghai Endometrial Cancer Study (1997-2003), a population-based case-control study of 1,204 endometrial cancer cases and 1,212 controls. Dietary information was obtained by use of a validated food frequency questionnaire. Genotypes of CYP19A1 at rs28566535, rs1065779, rs752760, rs700519, and rs1870050 were available for 1,042 cases and 1,035 controls. Unconditional logistic regression models were used to calculate odds ratios and their 95% confidence intervals after adjustment for potential confounding factors. Higher intake of soy foods and tea consumption were both inversely associated with the risk of endometrial cancer, with odds ratios of 0.8 (95% confidence interval: 0.6, 1.0) for the highest versus the lowest tertiles of intake of soy and 0.8 (95% confidence interval: 06, 0.9) for ever tea consumption. The association of single nucleotide polymorphisms rs1065779, rs752760, and rs1870050 with endometrial cancer was modified by tea consumption (p(interaction) < 0.05) but not by soy isoflavone intake. The authors' findings suggest that tea polyphenols may modify the effect of CYP19A1 genetic polymorphisms on the development of endometrial cancer.
某些多酚会抑制芳香化酶的活性，芳香化酶是雌激素合成中的一种关键酶，由CYP19A1基因编码。因此，食用富含多酚的食物和饮料可能会在子宫内膜癌的发生发展过程中与CYP19A1基因多态性相互作用。作者在上海子宫内膜癌研究（1997 - 2003年）中检验了这一假设，该研究是一项基于人群的病例对照研究，涉及1204例子宫内膜癌病例和1212名对照。通过使用经过验证的食物频率问卷获取饮食信息。1042例病例和1035名对照的CYP19A1基因在rs28566535、rs1065779、rs752760、rs700519和rs1870050位点的基因型信息可用。在对潜在混杂因素进行调整后，使用无条件逻辑回归模型计算比值比及其95%置信区间。大豆食品摄入量较高和饮茶与子宫内膜癌风险均呈负相关，大豆摄入量最高三分位数与最低三分位数相比，比值比为0.8（95%置信区间：0.6，1.0），曾经饮茶者的比值比为0.8（95%置信区间：0.6，0.9）。单核苷酸多态性rs1065779、rs752760和rs1870050与子宫内膜癌的关联受到饮茶的影响（交互作用p < 0.05），但不受大豆异黄酮摄入量的影响。作者的研究结果表明，茶多酚可能会改变CYP19A1基因多态性对子宫内膜癌发生发展的影响。
