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莳萝脑和芹子烯作为寄生曲霉中黄曲霉毒素G1生物合成的特异性抑制剂。

Dillapiol and Apiol as specific inhibitors of the biosynthesis of aflatoxin G1 in Aspergillus parasiticus.

作者信息

Razzaghi-Abyaneh Mehdi, Yoshinari Tomoya, Shams-Ghahfarokhi Masoomeh, Rezaee Mohammad-Bagher, Nagasawa Hiromichi, Sakuda Shohei

机构信息

Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.

出版信息

Biosci Biotechnol Biochem. 2007 Sep;71(9):2329-32. doi: 10.1271/bbb.70264. Epub 2007 Sep 7.

DOI:10.1271/bbb.70264
PMID:17827697
Abstract

Dillapiol was isolated from the essential oil of dill as a specific inhibitor of aflatoxin G1 production. It inhibited aflatoxin G1 production by Aspergillus parasiticus with an IC50 value of 0.15 microM without inhibiting aflatoxin B1 production or fungal growth. Apiol and myristicin, congeners of dillapiol, showed similar activity with IC50 values of 0.24 and 3.5 microM, respectively.

摘要

莳萝脑是从莳萝精油中分离出来的，作为黄曲霉毒素G1产生的特异性抑制剂。它抑制寄生曲霉产生黄曲霉毒素G1，IC50值为0.15微摩尔，而不抑制黄曲霉毒素B1的产生或真菌生长。莳萝脑的同系物芹菜脑和肉豆蔻醚表现出类似的活性，IC50值分别为0.24和3.5微摩尔。

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