Mongkoltanatus Jitima, Wangkaew Suparaporn, Kasitanon Nuntana, Louthrenoo Worawit
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Rheumatol Int. 2008 Feb;28(4):339-44. doi: 10.1007/s00296-007-0442-2. Epub 2007 Sep 6.
To study the prevalence, and clinical and laboratory manifestations of male lupus, and compare these findings with their age-matched female lupus in Thai patients. The medical records of patients with diagnosed Systemic lupus erythematosus (SLE) were reviewed. The clinical and laboratory manifestations were determined. There were 37 males in 508 patients with SLE (7.3%). There was no difference in mean +/- SD age and disease duration between male patients and their 74 female age-matched controls. When compared with females, male lupus patients had a significantly lower prevalence of alopecia (13.6 vs. 44.6%, P = 0.001), arthralgia (2.7 vs. 17.6%, P = 0.032), Raynaud's phenomenon (0.0 vs. 12.2%, P = 0.027), and psychosis (0.0 vs. 13.5%, P = 0.029), but they had a significantly higher prevalence of thrombocytopenia (32.4 vs. 12.2%, P = 0.019) and renal insufficiency (40.5 vs. 16.4%, P = 0.006). Our study showed several existing sex-related differences in the clinical manifestations in Thai SLE patients.
研究泰国男性狼疮患者的患病率、临床及实验室表现，并将这些结果与年龄匹配的女性狼疮患者进行比较。回顾诊断为系统性红斑狼疮（SLE）患者的病历，确定其临床及实验室表现。508例SLE患者中有37例男性（7.3%）。男性患者与其74例年龄匹配的女性对照在平均±标准差年龄及病程方面无差异。与女性相比，男性狼疮患者脱发（13.6%对44.6%，P = 0.001）、关节痛（2.7%对17.6%，P = 0.032）、雷诺现象（0.0%对12.2%，P = 0.027）及精神病（0.0%对13.5%，P = 0.029）的患病率显著较低，但血小板减少症（32.4%对12.2%，P = 0.019）及肾功能不全（40.5%对16.4%，P = 0.006）的患病率显著较高。我们的研究显示泰国SLE患者在临床表现方面存在一些现有的性别相关差异。
