Stjernman Henrik, Grännö Christer, Järnerot Gunnar, Ockander Leif, Tysk Curt, Blomberg Björn, Ström Magnus, Hjortswang Henrik
Division of Gastroenterology, Department of Medicine, County Hospital Ryhov, Jönköping; Sweden.
Inflamm Bowel Dis. 2008 Jan;14(1):47-52. doi: 10.1002/ibd.20255.
Health-related quality of life (HRQoL) is an essential part of inflammatory bowel disease (IBD) assessment. The Short Health Scale (SHS), an HRQoL questionnaire in which the patients rate the disease impact on 4 important aspects of subjective health (symptoms, function, worry, and general well-being) was demonstrated in a previous study to be valid, reliable, and responsive in patients with ulcerative colitis. The present study evaluates the SHS in patients with Crohn's disease (CD).
In all, 367 CD patients completed the SHS and 4 other HRQoL questionnaires (IBDQ, SF-36, RFIPC, and PGWB) at their regular outpatient visits. Then 330 patients completed the questionnaires at a second visit 6 months later. In addition, reliability data were obtained from repeat measurements 4 weeks after the first visit in 40 patients stable in remission.
Patients in remission scored better on all 4 questions than those with active disease (P < 0.001). All 4 questions were strongly correlated with the corresponding dimensions of the other HRQoL questionnaires (r(s) = 0.74-0.83). Reliability was confirmed with strong test-retest correlations (r(s) = 0.69-0.82) and intraclass correlation coefficients (0.66-0.77). Patients who changed from remission to active disease or vice versa showed a significant change in all 4 SHS scores (P < 0.005).
SHS is a valid, reliable and responsive HRQoL instrument also in patients with CD. It is easily completed by the patient and requires no further calculation by the investigator. SHS gives a comprehensive overview of the main aspects of the patient's subjective health perception and is a useful tool in both clinical practice and clinical studies.
健康相关生活质量（HRQoL）是炎症性肠病（IBD）评估的重要组成部分。简短健康量表（SHS）是一种HRQoL问卷，患者可对疾病对主观健康的4个重要方面（症状、功能、担忧和总体幸福感）的影响进行评分。先前一项研究表明，该量表在溃疡性结肠炎患者中具有有效性、可靠性和反应性。本研究对克罗恩病（CD）患者进行SHS评估。
共有367例CD患者在定期门诊就诊时完成了SHS及其他4种HRQoL问卷（IBDQ、SF - 36、RFIPC和PGWB）。然后，330例患者在6个月后的第二次就诊时完成了这些问卷。此外，从40例病情稳定处于缓解期的患者首次就诊4周后的重复测量中获得了可靠性数据。
缓解期患者在所有4个问题上的得分均高于活动期患者（P < 0.001）。所有4个问题与其他HRQoL问卷的相应维度均呈强相关（r(s) = 0.74 - 0.83）。通过强重测相关性（r(s) = 0.69 - 0.82）和组内相关系数（0.66 - 0.77）证实了可靠性。从缓解期转变为活动期或反之的患者在所有4个SHS得分上均有显著变化（P < 0.005）。
SHS在CD患者中也是一种有效、可靠且具有反应性的HRQoL工具。患者易于完成，研究者无需进一步计算。SHS全面概述了患者主观健康感知的主要方面，是临床实践和临床研究中的有用工具。
