D'Amico D, Leone M, Macciardi F, Valentini S, Bussone G
Centro Cefalee, Istituto Nazionale Neurologico, C. Besta, Milano.
Ital J Neurol Sci. 1991 Dec;12(6):581-4. doi: 10.1007/BF02336955.
68 randomly selected patients with migraine without aura (M) and 4 generations of their relatives (N = 394) were studied in order to probe the genetic hypothesis of migraine. Significantly more of the probands were women and M was significantly more frequent among female relatives. Earlier onset was commoner among male probands. A genetic component of M is indicated by the very high frequency of at least one affected relative (85.3%) and by a disease prevalence that is similar among both first and second degree relatives. A simple autosomal mode of transmission seems unlikely from analysis of the data on the affected relatives, while a "sex-limited" transmission mode is suggested.
为了探究偏头痛的遗传假说，对68名随机选取的无先兆偏头痛患者（M组）及其4代亲属（N = 394）进行了研究。先证者中女性明显更多，且M在女性亲属中明显更常见。男性先证者发病较早更为常见。至少有一名患病亲属的频率非常高（85.3%）以及一级和二级亲属中疾病患病率相似，这表明M存在遗传成分。从对患病亲属数据的分析来看，简单的常染色体遗传模式似乎不太可能，而提示存在“性别限制”遗传模式。
