Devoto M, Lozito A, Staffa G, D'Alessandro R, Sacquegna T, Romeo G
Cephalalgia. 1986 Jun;6(2):101-5. doi: 10.1046/j.1468-2982.1986.0602101.x.
To test the existence of inherited liability to migraine, formal segregation analysis of family data collected from 128 patients has been performed. Patients were subdivided into three groups in accordance with the presence or absence of migraine in their parents. The results obtained in each group were then compared with those expected on the basis of two different modes of simple Mendelian inheritance, namely autosomal dominant and autosomal recessive transmission. Our data show that neither of the two hypotheses can be accepted, thus suggesting the existence of a possible genetic heterogeneity of liability to migraine.
为了检验偏头痛遗传易感性的存在，我们对从128名患者收集的家庭数据进行了正式的分离分析。根据患者父母是否患有偏头痛，将患者分为三组。然后将每组获得的结果与基于两种不同的简单孟德尔遗传模式（即常染色体显性遗传和常染色体隐性遗传）预期的结果进行比较。我们的数据表明，这两种假设均不能被接受，因此提示偏头痛易感性可能存在遗传异质性。
