Ishii H, Kobayashi J, Ishikawa M, Haginiwa J, Ishikawa T
Faculty of Pharmaceuticeutical Sciences, Chiba University, Japan.
Yakugaku Zasshi. 1991 Jul;111(7):365-75. doi: 10.1248/yakushi1947.111.7_365.
Chemical constituents of the root bark of Toddalia asiatica (L.) Lam. (T. aculeata Pers.), Rutaceae, were examined. In addition to twelve known coumarins [toddaculin (2), coumurrayin (5), toddanone (6), 8-(3,3-dimethylallyl)-6,7-dimethoxycoumarin (7), isopimpinellin (8), 6-(3-chloro-2-hydroxy-3-methylbutyl)-5,7-dimethoxycoumarin (9), 6-formyllimettin (10), 5,7,8-trimethoxycoumarin (12), toddasin (13), (+)-toddanol (14), 6-(2-hydroxy-3-methoxy-3-methylbutyl)-5,7-dimethoxycoumarin (18), and toddalolactone (21)] five new coumarins [toddalenol (17), toddalosin (19), 5-methoxysuberenon (23), toddalenone (24), and 8-formyllimettin (25)] were isolated. Furthermore seven known benzo[c]phenanthridine alkaloids [des-N-methylchelerythrine (4), oxychelerythrine (15), arnottianamide (16), oxyavicine (22), avicine (30), chelerythrine (31), and chelerythrine-psi-cyanide (34)] and four known quinoline alkaloids [N-methylflindersine (11), 4-methoxy-1-methyl-2-quinolone (20), skimmianine (35), integriquinolone (36)], one known triterpenoid [beta-amyrin (3)], and four unknown components [unknown I-IV (26)-(29)] were isolated.
对芸香科植物飞龙掌血（Toddalia asiatica (L.) Lam.，即T. aculeata Pers.）根皮的化学成分进行了研究。除了12种已知香豆素类化合物[飞龙掌血苦内酯（2）、豆寇明（5）、飞龙掌血酮（6）、8-(3,3-二甲基烯丙基)-6,7-二甲氧基香豆素（7）、异茴芹内酯（8）、6-(3-氯-2-羟基-3-甲基丁基)-5,7-二甲氧基香豆素（9）、6-甲酰基梨莓素（10）、5,7,8-三甲氧基香豆素（12）、飞龙掌血辛（13）、(+)-飞龙掌血醇（14）、6-(2-羟基-3-甲氧基-3-甲基丁基)-5,7-二甲氧基香豆素（18）和飞龙掌血内酯（21）]外，还分离出了5种新香豆素类化合物[飞龙掌血醇（17）、飞龙掌血辛（19）、5-甲氧基苏贝酮（23）、飞龙掌血酮（24）和8-甲酰基梨莓素（25）]。此外，还分离出了7种已知的苯并[c]菲啶生物碱[去-N-甲基白屈菜红碱（4）、氧化白屈菜红碱（15）、阿诺替酰胺（16）、氧化阿维辛（22）、阿维辛（30）、白屈菜红碱（31）和白屈菜红碱-ψ-氰化物（34）]以及4种已知的喹啉生物碱[N-甲基弗林德辛（11）、4-甲氧基-1-甲基-2-喹诺酮（20）、茵芋碱（35）、整合喹诺酮（36）]、1种已知的三萜类化合物[β-香树脂醇（3）]和4种未知成分[未知物I-IV（26）-(29)]。
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