来自台湾软珊瑚直枝软珊瑚的倍半萜类化合物和人工合成的19-氧化甾体化合物。

Sesquiterpenoids and artificial 19-oxygenated steroids from the formosan soft coral Nephthea erecta.

作者信息

Cheng Shi-Yie, Dai Chang-Feng, Duh Chang-Yih

机构信息

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.

出版信息

J Nat Prod. 2007 Sep;70(9):1449-53. doi: 10.1021/np070189t. Epub 2007 Sep 11.

DOI:10.1021/np070189t

PMID:17845002

Abstract

Chemical investigations on the acetone and MeOH solubles of the soft coral Nephthea erecta have afforded five new sesquiterpenoids (1-5), one known sesquiterpene, kelsoene (6), and two known 19-oxygenated steroids (10 and 11). In addition, three unexpected artificial 19-oxygenated steroids (7-9) were obtained by letting 10 and 11 stand in CDCl(3) for prolonged periods of time. The structures of 1-9 were elucidated by extensive spectroscopic analyses, and their cytotoxicity against selected cancer cells was measured in vitro.

摘要

对软珊瑚直立软珊瑚（Nephthea erecta）的丙酮和甲醇可溶物进行化学研究，得到了5个新的倍半萜类化合物（1-5）、1个已知的倍半萜——凯尔索烯（6）以及2个已知的19-氧化甾体（10和11）。此外，通过将10和11在CDCl₃中长时间放置，得到了3个意外的人工合成19-氧化甾体（7-9）。通过广泛的光谱分析阐明了1-9的结构，并在体外测定了它们对选定癌细胞的细胞毒性。