Russell A S
Clin Exp Immunol. 1975 Dec;22(3):457-60.
We have looked at evidence for the transplacental passage of cell-mediated immunity in man. The lymphocyte response of mother-neonate pairs was assessed to non-specific mitogens, allogeneic cells, and to microbial antigens. Although six mothers were known to be chronic carriers of Herpes simplex virus only one of their neonates responded to this viral antigen. On two occasions a lymphocyte response was induced in cord blood by antigens to which the mother did not respond. This paradox remains unexplained. We suggest that the relative immunity of the neonate to some infectious diseases does not depend on the transplacental passage of cellular immunity.
我们研究了人类细胞介导免疫经胎盘传递的证据。评估了母婴对非特异性有丝分裂原、同种异体细胞和微生物抗原的淋巴细胞反应。尽管已知有6位母亲是单纯疱疹病毒的慢性携带者，但她们的新生儿中只有1例对这种病毒抗原有反应。有两次，脐带血中的淋巴细胞对母亲无反应的抗原产生了反应。这一矛盾现象仍无法解释。我们认为，新生儿对某些传染病的相对免疫并不依赖于细胞免疫的经胎盘传递。
