Feinberg I, Jones R, Walker J, Cavness C, Floyd T
Clin Pharmacol Ther. 1976 Jun;19(6):782-94. doi: 10.1002/cpt1976196782.
Marijuana extract, given in daily doses containing 70 to 210 mg delta-9-tetrahydrocannabinol (THC), induced effects on sleep that were virtually identical to those produced by the same doses of relatively pure (96%) THC. Both drugs reduced eye movements density with some tolerance developing to this effect. Stage 4 tendend to increase with drug administration. Abrupt withdrawal led to extremely high densities of eye movement, increased rapid eye movement (REM) durations, and a sharp but transient fall in stage 4 to baseline levels. These effects may be useful in the elucidation of the pharmacology of sleep. The effects on sleep of THC administration (but not withdrawal) closely resemble those induced by lithium. For this reason, we suggest further studies of THC in affective disorders. Evidence available thus far suggests that THC produces dysphoric symptoms in unipolar but not in bipolar depressed patients; these differences in response may prove of diagnostic value. An adequate therapeutic trial of THC in bipolar depressed patients has not yet been carried out.
大麻提取物，每日剂量含70至210毫克δ-9-四氢大麻酚（THC），对睡眠产生的影响与相同剂量的相对纯（96%）THC产生的影响几乎相同。两种药物都降低了眼动密度，对此效应会产生一定耐受性。给药后第4期睡眠往往会增加。突然停药会导致极高的眼动密度、快速眼动（REM）持续时间增加，以及第4期睡眠急剧但短暂地降至基线水平。这些效应可能有助于阐明睡眠药理学。THC给药（而非停药）对睡眠的影响与锂诱导的影响非常相似。因此，我们建议对THC在情感障碍中的作用进行进一步研究。迄今为止可得的证据表明，THC在单相抑郁患者中会产生烦躁症状，而在双相抑郁患者中则不会；这些反应差异可能具有诊断价值。尚未对双相抑郁患者进行充分的THC治疗试验。
