Liu Guangwei, Zhao Yong
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Immunology. 2007 Oct;122(2):149-56. doi: 10.1111/j.1365-2567.2007.02651.x.
Regulatory CD4(+) CD25(+) T (Treg) cells with the ability to suppress host immune responses against self- or non-self antigens play important roles in the processes of autoimmunity, transplant rejection, infectious diseases and cancers. The proper regulation of CD4(+) CD25(+) Treg cells is thus critical for optimal immune responses. Toll-like receptor (TLR)-mediated recognition of specific structures of invading pathogens initiates innate as well as adaptive immune responses via antigen-presenting cells (APCs). Interestingly, new evidence suggests that TLR signalling may directly or indirectly regulate the immunosuppressive function of CD4(+) CD25(+) Treg cells in immune responses. TLR signalling may shift the balance between CD4(+) T-helper cells and Treg cells, and subsequently influence the outcome of the immune response. This immunomodulation pathway may therefore have potential applications in the treatment of graft rejection, autoimmune diseases, infection diseases and cancers.
具有抑制宿主针对自身或非自身抗原的免疫反应能力的调节性CD4(+) CD25(+) T（Treg）细胞，在自身免疫、移植排斥、传染病和癌症过程中发挥着重要作用。因此，对CD4(+) CD25(+) Treg细胞的适当调节对于最佳免疫反应至关重要。Toll样受体（TLR）介导的对入侵病原体特定结构的识别，通过抗原呈递细胞（APC）启动先天性和适应性免疫反应。有趣的是，新证据表明TLR信号传导可能直接或间接调节免疫反应中CD4(+) CD25(+) Treg细胞的免疫抑制功能。TLR信号传导可能会改变CD4(+)辅助性T细胞和Treg细胞之间的平衡，进而影响免疫反应的结果。因此，这种免疫调节途径可能在治疗移植排斥、自身免疫性疾病、感染性疾病和癌症方面具有潜在应用。
