Gu Tao, Ma Xiang-Xing, Xu Yan-Hong, Xiu Jian-Jun, Li Chuan-Fu
Department of Radiology, Qilu Hospital of Shandong University, Jinan 250012, China.
Neurol Res. 2008 Apr;30(3):229-33. doi: 10.1179/016164107X235473. Epub 2007 Sep 10.
To investigate the metabolite concentration ratios including N-acetylaspartate (NAA), choline-containing compounds (Cho) and creatine plus phosphocreatine (Cr) in thalami of patients with migraine without aura, patients with trigeminal neuralgia and healthy comparison subjects using multi-voxel proton magnetic resonance spectroscopy (1H-MRS).
1H-MRS was performed with a 3.0 T MR system on the thalamus bilaterally in 20 patients with migraine without aura, 16 patients with trigeminal neuralgia and 14 healthy control subjects.
In the patients with trigeminal neuralgia, metabolite concentration ratios except for Cho/Cr in thalami were different from those of healthy subjects (p>0.05). In migraine group, only NAA/Cho is low in the left thalamus (p>0.05). Comparing the metabolite concentration ratios of affected and contralateral sides in migraine and trigeminal neuralgia groups, only NAA/Cr showed a significant difference (p>0.05).
It was proved that migraine and trigeminal neuralgia seemed to be associated with an abnormal balance of the neural activity in the thalamus using 1H-MRS. There was some significant difference between metabolite concentration ratios in two diseases. 1H-MRS may serve as a useful non-invasive tool for evaluating thalamic neural activity and therapy effect in clinical performance of patients with migraine without aura.
使用多体素质子磁共振波谱（1H-MRS）研究无先兆偏头痛患者、三叉神经痛患者以及健康对照者丘脑的代谢物浓度比值，包括N-乙酰天门冬氨酸（NAA）、含胆碱化合物（Cho）和肌酸加磷酸肌酸（Cr）。
采用3.0T磁共振系统对20例无先兆偏头痛患者、16例三叉神经痛患者和14例健康对照者双侧丘脑进行1H-MRS检查。
三叉神经痛患者丘脑的代谢物浓度比值中，除Cho/Cr外，均与健康受试者不同（p>0.05）。偏头痛组仅左侧丘脑的NAA/Cho较低（p>0.05）。比较偏头痛和三叉神经痛组患侧与对侧的代谢物浓度比值，仅NAA/Cr有显著差异（p>0.05）。
通过1H-MRS证实，偏头痛和三叉神经痛似乎与丘脑神经活动的异常平衡有关。两种疾病的代谢物浓度比值存在一些显著差异。1H-MRS可作为评估无先兆偏头痛患者临床中丘脑神经活动和治疗效果的有用非侵入性工具。
