靛玉红甲素，一种从菘蓝叶中提取的具有前所未有的骨架的新型生物碱。
Isatisine A, a novel alkaloid with an unprecedented skeleton from leaves of Isatis indigotica.
作者信息
Liu Ji-Feng, Jiang Zhi-Yong, Wang Rui-Rui, Zheng Yong-Tang, Chen Ji-Jun, Zhang Xue-Mei, Ma Yun-Bao
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PRC.
出版信息
Org Lett. 2007 Oct 11;9(21):4127-9. doi: 10.1021/ol701540y. Epub 2007 Sep 13.
9alpha,13alpha-Dihydroxylisopropylidenylisatisine A (1), which was derived from isatisine A (2) and possessed an unprecedented fused pentacyclic skeleton, was isolated from the leaves of Isatis indigotica Fort. The structure and relative configuration were elucidated on the basis of extensive NMR analyses and finally determined by single-crystal X-ray diffraction. Compound 1 showed moderate anti-HIV-1 activity with EC50 = 37.8 microM and SI = 7.98.
9α,13α-二羟基异亚丙基靛玉红A（1）是从菘蓝叶中分离得到的，它由靛玉红A（2）衍生而来，具有前所未有的稠合五环骨架。通过广泛的核磁共振分析阐明了其结构和相对构型，并最终通过单晶X射线衍射确定。化合物1表现出中等的抗HIV-1活性，EC50 = 37.8微摩尔，SI = 7.98。
Zotero 插件