Xiao Wei-Lie, Li Rong-Tao, Li Sheng-Hong, Li Xiao-Li, Sun Han-Dong, Zheng Yong-Tang, Wang Rui-Rui, Lu Yang, Wang Cheng, Zheng Qi-Tai
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P R China.
Org Lett. 2005 Mar 31;7(7):1263-6. doi: 10.1021/ol0473187.
[structures: see text] Lancifodilactone F (1), possessing an unprecedented rearranged pentanortriterpenoid backbone derived from cycloartane, was isolated from the leaves and stems of Schisandra lancifolia (Rehd. et Wils) A. C. Smith. Its structure was established by comprehensive NMR and MS spectroscopic analysis, coupled with single-crystal X-ray experiment. Compound 1 exerted minimal cytotoxicity against C8166 cells (CC50 > 200 microg/mL) and showed anti-HIV activity with EC50 = 20.69 +/- 3.31 microg/mL and a selectivity index > 6.62.
[结构：见正文] 从华中五味子（Schisandra lancifolia (Rehd. et Wils) A. C. Smith）的叶和茎中分离得到了兰西弗内酯F（1），其具有源自环阿尔廷烷的前所未有的重排五环三萜骨架。通过全面的核磁共振（NMR）和质谱（MS）光谱分析，并结合单晶X射线实验确定了其结构。化合物1对C8166细胞的细胞毒性极小（半数细胞毒性浓度（CC50）> 200 μg/mL），并显示出抗HIV活性，半数有效浓度（EC50）= 20.69 ± 3.31 μg/mL，选择性指数> 6.62。
