来自雪胆的块茎的具HIV-1抑制活性的八降葫芦烷型和葫芦烷型三萜类化合物

Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity.

作者信息

Chen Jian-Chao, Zhang Gao-Hong, Zhang Zhong-Quan, Qiu Ming-Hua, Zheng Yong-Tang, Yang Liu-Meng, Yu Kai-Bei

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, People's Republic of China.

出版信息

J Nat Prod. 2008 Jan;71(1):153-5. doi: 10.1021/np0704396. Epub 2007 Dec 19.

DOI:10.1021/np0704396

PMID:18088099

Abstract

Two new cucurbitacins, endecaphyllacins A (1) and B (2), together with six known analogues (3-8), were isolated from the tubers of Hemsleya endecaphylla. The structures of 1 and 2 were elucidated by NMR and MS spectroscopic analysis. The relative stereochemistry of 1 was determined by single-crystal X-ray diffraction. Compound 4 (cucurbitacin B) showed potent anti-HIV-1 in C8166 cells (EC=0.09 microg/mL) with a selectivity index of 16.7.

摘要

从雪胆的块茎中分离出两种新的葫芦素，即十一叶雪胆素A（1）和B（2），以及六种已知类似物（3 - 8）。通过核磁共振（NMR）和质谱（MS）光谱分析阐明了1和2的结构。1的相对立体化学通过单晶X射线衍射确定。化合物4（葫芦素B）在C8166细胞中显示出有效的抗HIV - 1活性（EC = 0.09微克/毫升），选择性指数为16.7。