缺氧诱导的心血管系统信号传导
Hypoxia-induced signaling in the cardiovascular system.
作者信息
Simon M Celeste, Liu Liping, Barnhart Bryan C, Young Regina M
机构信息
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Annu Rev Physiol. 2008;70:51-71. doi: 10.1146/annurev.physiol.70.113006.100526.
Abstract
Low oxygen (O2) levels are a naturally occurring feature of embryonic development, adult physiology, and diseases such as those of the cardiovascular system. Although many responses to O2 deprivation are mediated by hypoxia-inducible factors (HIFs), researchers are finding a growing number of HIF-independent pathways that promote O2 conformance and hypoxia tolerance. Here, we describe HIF-independent responses and how they impact cardiovascular tissue homeostasis.
摘要
低氧水平是胚胎发育、成体生理学以及诸如心血管系统疾病等病症中自然存在的特征。尽管对缺氧的许多反应是由缺氧诱导因子（HIFs）介导的，但研究人员发现越来越多不依赖HIF的途径可促进氧顺应性和缺氧耐受性。在此，我们描述不依赖HIF的反应及其如何影响心血管组织稳态。
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