Crawshaw Timothy R, Brown Ian H, Essen Steve C, Young Stuart C L
Veterinary Laboratories Agency Staplake Mount, Starcross, Exeter, Devon EX6 8PE, UK.
Vet J. 2008 Oct;178(1):98-102. doi: 10.1016/j.tvjl.2007.07.022. Epub 2007 Sep 11.
Sporadic cases of an acute fall in milk production, "milk drop", were investigated in a Holstein Friesian dairy herd in Devon. The investigation was a case control study with two controls per case. Paired blood samples demonstrated that rising antibody titres to human influenza A/England/333/80 (H1N1) and human influenza A/Eng/427/88 (H3N2) were associated with an acute fall in milk production. Rising titres to bovine respiratory syncytial virus (BRSV), bovine virus diarrhoea virus (BVD), infectious bovine rhinotracheitis (IBR) and parainfluenza virus 3 (PI3) were not associated with an acute fall in milk production. Cases with rises in antibody to influenza A had significantly higher respiratory scores and rectal temperatures than their controls. The mean loss of milk production for the cases with rises in antibody to influenza A compared to their controls was 159.9L. This study provides further evidence that influenza A persists in cattle and causes clinical disease.
在德文郡的一个荷斯坦弗里生奶牛群中，对散发性急性产奶量下降（“奶量下降”）病例进行了调查。该调查是一项病例对照研究，每个病例有两个对照。配对血样显示，针对甲型人流感病毒/英格兰/333/80（H1N1）和甲型人流感病毒/英格兰/427/88（H3N2）的抗体滴度上升与产奶量急性下降有关。针对牛呼吸道合胞体病毒（BRSV）、牛病毒性腹泻病毒（BVD）、传染性牛鼻气管炎（IBR）和副流感病毒3型（PI3）的抗体滴度上升与产奶量急性下降无关。甲型流感抗体上升的病例其呼吸评分和直肠温度显著高于其对照。与对照相比，甲型流感抗体上升的病例产奶量平均损失159.9升。这项研究提供了进一步的证据，证明甲型流感在牛群中持续存在并导致临床疾病。
