State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China.
Chem Soc Rev. 2012 May 7;41(9):3679-98. doi: 10.1039/c2cs15308d. Epub 2012 Mar 22.
In the past decade, non-invasive and biocompatible mesoporous silica materials as efficient drug delivery systems have attracted special attention. Great progress in structure control and functionalization (magnetism and luminescence) design has been achieved for biotechnological and biomedical applications. This review highlights the most recent research progress on silica-based controlled drug delivery systems, including: (i) pure mesoporous silica sustained-release systems, (ii) magnetism and/or luminescence functionalized mesoporous silica systems which integrate targeting and tracking abilities of drug molecules, and (iii) stimuli-responsive controlled release systems which are able to respond to environmental changes, such as pH, redox potential, temperature, photoirradiation, and biomolecules. Although encouraging and potential developments have been achieved, design and mass production of novel multifunctional carriers, some practical biological application, such as biodistribution, the acute and chronic toxicities, long-term stability, circulation properties and targeting efficacy in vivo are still challenging.
在过去的十年中，作为高效药物传递系统的非侵入性和生物相容性介孔硅材料引起了特别关注。在生物技术和生物医学应用方面，在结构控制和功能化（磁性和发光）设计方面已经取得了巨大进展。本文重点介绍了基于硅的控释药物传递系统的最新研究进展，包括：（i）纯介孔硅缓释系统，（ii）磁性和/或发光功能化介孔硅系统，其整合了药物分子的靶向和跟踪能力，以及（iii）能够响应环境变化（如 pH 值、氧化还原电位、温度、光辐射和生物分子）的刺激响应控释系统。尽管已经取得了令人鼓舞和潜在的发展，但设计和大规模生产新型多功能载体、一些实际的生物应用，如生物分布、急性和慢性毒性、长期稳定性、循环特性和体内靶向效果仍然具有挑战性。
