从北极苔藓虫 Tegella cf. spitzbergensis 中分离得到的具有抗菌活性的化合物 ent-eusynstyelamide B 和 eusynstyelamides D、E、F。

The antibacterial ent-eusynstyelamide B and eusynstyelamides D, E, and F from the Arctic bryozoan Tegella cf. spitzbergensis.

机构信息

Norwegian College of Fishery Science, University of Tromsø, Breivika N-9037, Tromsø, Norway.

出版信息

J Nat Prod. 2011 Apr 25;74(4):837-41. doi: 10.1021/np100499c. Epub 2011 Mar 3.

Abstract

The brominated tryptophan-derived ent-eusynstyelamide B (1) and three new derivatives, eusynstyelamides D, E, and F (2-4), were isolated from the Arctic bryozoan Tegella cf. spitzbergensis. The structures were elucidated by spectroscopic methods including 1D and 2D NMR and analysis of mass spectrometric data. The enantiomer of 1, eusynstyelamide B, has previously been isolated from the Australian ascidian Eusynstyela latericius. Antimicrobial activities are here reported for 1-4, with minimum inhibitory concentrations (MIC) as low as 6.25 μg/mL for 1 and 4 against Staphylococcus aureus. Eusynstyelamides 2 and 3 showed weak cytotoxic activity against the human melanoma A 2058 cell line.

摘要

从北极苔藓虫 Tegella cf. spitzbergensis 中分离得到溴代色氨酸衍生的-ent- Eusynstyelamide B（1）和三个新衍生物， Eusynstyelamides D、E 和 F（2-4）。通过包括 1D 和 2D NMR 以及质谱数据分析在内的光谱方法阐明了这些结构。Eusynstyelamide B 的对映异构体 1 以前已从澳大利亚海鞘 Eusynstyela latericius 中分离得到。本文报道了 1-4 的抗菌活性，其最低抑菌浓度（MIC）低至 6.25μg/mL，对金黄色葡萄球菌有抑制作用。Eusynstyelamides 2 和 3 对人黑色素瘤 A 2058 细胞系表现出较弱的细胞毒性活性。