纳米金在生物制药中的应用。
Biopharmaceutical applications of nanogold.
机构信息
Kayyali Chair for Pharmaceutical Industries, Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia.
Kayyali Chair for Pharmaceutical Industries, Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia ; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut-71526, Egypt.
出版信息
Saudi Pharm J. 2010 Oct;18(4):179-93. doi: 10.1016/j.jsps.2010.07.002. Epub 2010 Jul 24.
Abstract
The application of nanogold in biopharmaceutical field is reviewed in this work. The properties of nanogold including nanogold surface Plasmon absorption and nanogold surface Plasmon light scattering are illustrated. The physical, chemical, biosynthesis methods of nanogold preparation are presented. Catalytic properties as well as biomedical applications are highlighted as one of the most important applications of nanogold. Biosensing, and diagnostic and therapeutic applications of gold nanoparticles are evaluated. Moreover, gold nanoparticles in drugs, biomolecules and proteins' delivery are analyzed. Gold nanoparticles for the site-directed photothermal applications are reviewed as the most fruitful research area in the future.
摘要
本工作综述了纳米金在生物制药领域的应用。阐述了纳米金的性质，包括纳米金表面等离子体吸收和纳米金表面等离子体光散射。介绍了纳米金的物理、化学、生物合成制备方法。重点介绍了纳米金作为最重要的应用之一的催化性能以及生物医学应用。评价了金纳米粒子在生物传感、诊断和治疗中的应用。此外，还分析了金纳米粒子在药物、生物分子和蛋白质传递中的应用。综述了金纳米粒子在靶向光热应用方面的研究，这是未来最有成效的研究领域。
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