侧柏果皮中的二萜类化合物。

Diterpenoids from the pericarp of Platycladus orientalis.

作者信息

Wang Ya-Zhou, Tang Chun-Ping, Ke Chang-Qiang, Weiss Hans-Christoph, Gesing Ernst-Rudolf, Ye Yang

机构信息

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-Chong-Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China.

出版信息

Phytochemistry. 2008 Jan;69(2):518-26. doi: 10.1016/j.phytochem.2007.07.023. Epub 2007 Sep 12.

DOI:10.1016/j.phytochem.2007.07.023

PMID:17854849

Abstract

Eight labdane-type diterpenes, 7beta,13S-dihydroxylabda-8(17),14-dien-19-oic acid (1), 12R,15-dihydroxylabda-8(17),13E-dien-19-oic acid (3c), 12R,15-dihydroxylabda-8(17),13Z-dien-19-oic acid (3d), 12R,13R,14S-trihydroxylabda-12,15-epoxy-8(17)-en-19-oic acid (4a), 12S,13S,14R-trihydroxylabda-12,15-epoxy-8(17)-en-19-oic acid (4b), 15-hydroxy-12-oxolabda-8(17),13E-dien-19-oic acid (5), 14R,15-dihydroxylabda-8(17),12Z-dien-19-oic acid (7a) and 14S,15-dihydroxylabda-8(17),12Z-dien-19-oic acid (7b), along with 20 known diterpenoids, were isolated from the pericarp of Platycladus orientalis. Their structures were unambiguously elucidated by NMR spectroscopic and single crystal X-ray diffraction analyses, as well as via chemical correlation conversion. NMR spectroscopic data of known isomers 8c and 8d were reported as a supplement to existing data.

摘要

从侧柏的果皮中分离出8种半日花烷型二萜，7β,13S - 二羟基半日花 - 8(17),14 - 二烯 - 19 - 酸（1）、12R,15 - 二羟基半日花 - 8(17),13E - 二烯 - 19 - 酸（3c）、12R,15 - 二羟基半日花 - 8(17),13Z - 二烯 - 19 - 酸（3d）、12R,13R,14S - 三羟基半日花 - 12,15 - 环氧 - 8(17) - 烯 - 19 - 酸（4a）、12S,13S,14R - 三羟基半日花 - 12,15 - 环氧 - 8(17) - 烯 - 19 - 酸（4b）、15 - 羟基 - 12 - 氧代半日花 - 8(17),13E - 二烯 - 19 - 酸（5）、14R,15 - 二羟基半日花 - 8(17),12Z - 二烯 - 19 - 酸（7a）和14S,15 - 二羟基半日花 - 8(17),12Z - 二烯 - 19 - 酸（7b），以及20种已知的二萜类化合物。通过核磁共振光谱和单晶X射线衍射分析，以及化学相关转化，明确解析了它们的结构。已知异构体8c和8d的核磁共振光谱数据作为现有数据的补充进行了报道。