Michalikova S, Ennaceur A, van Rensburg R, Chazot P L
University of Sunderland, Sunderland Pharmacy School, Wharncliffe Street, Sunderland SR1 3SD, UK.
Neurobiol Learn Mem. 2008 May;89(4):480-8. doi: 10.1016/j.nlm.2007.07.014. Epub 2007 Sep 12.
Non-thermal near infra-red (IR) has been shown to have many beneficial photobiological effects on a range of cell types, including neurons. In the present study, a pretreatment with a daily 6 min exposure to IR1072 for 10 days yielded a number of significant behavioral effects on middle-aged female CD-1 mice (12-months) tested in a 3D-maze. Middle-aged mice show significant deficits in a working memory test and IR treatment reversed this deficit. Interestingly, the IR treated middle-aged group despite making less memory errors than sham middle-aged group spent longer time in different parts of the maze than both the young group (3-months) and sham-middle-aged group (12-months). Young mice appeared more anxious than middle-aged mice in the first sessions of the test. Exposure to IR appeared to have no significant effects upon exploratory activity or anxiety responses. However, it elicited significant effects on working memory, with the IR middle-aged mice being more considerate in their decision making, which results in an overall improved cognitive performance which is comparable to that of young CD-1 mice. The present study describes a novel method for assessing emotional responses and memory performance in a 3D spatial navigation task and demonstrates the validity of our new all-in-one test and its sensitivity to ageing and non-invasive beneficial IR treatment.
已证明非热近红外（IR）对包括神经元在内的一系列细胞类型具有许多有益的光生物学效应。在本研究中，对中年雌性CD-1小鼠（12个月大）进行为期10天、每天6分钟的IR1072预处理后，在3D迷宫测试中产生了许多显著的行为效应。中年小鼠在工作记忆测试中表现出明显缺陷，而IR处理逆转了这一缺陷。有趣的是，尽管接受IR处理的中年组比假手术中年组出现的记忆错误更少，但它们在迷宫不同区域花费的时间比年轻组（3个月大）和假手术中年组（12个月大）都要长。在测试的最初阶段，年轻小鼠似乎比中年小鼠更焦虑。暴露于IR对探索活动或焦虑反应似乎没有显著影响。然而，它对工作记忆产生了显著影响，接受IR处理的中年小鼠在决策时更加慎重，这导致其整体认知表现得到改善，与年轻的CD-1小鼠相当。本研究描述了一种在3D空间导航任务中评估情绪反应和记忆表现的新方法，并证明了我们新的一体化测试的有效性及其对衰老和非侵入性有益IR处理的敏感性。
