Zhao Chenguang, Li Dongwei, Kong Yuanjun, Liu Hongyu, Hu Yiqing, Niu Haijing, Jensen Ole, Li Xiaoli, Liu Hanli, Song Yan
State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
Center for Cognition and Neuroergonomics, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University at Zhuhai, Guangdong, China.
Sci Adv. 2022 Dec 2;8(48):eabq3211. doi: 10.1126/sciadv.abq3211.
Transcranial photobiomodulation (tPBM) is a safe and noninvasive intervention that has shown promise for improving cognitive performance. Whether tPBM can modulate brain activity and thereby enhance working memory (WM) capacity in humans remains unclear. In this study, we found that 1064-nm tPBM applied to the right prefrontal cortex (PFC) improves visual working memory capacity and increases occipitoparietal contralateral delay activity (CDA). The CDA set-size effect during retention mediated the effect between the 1064-nm tPBM and subsequent WM capacity. The behavioral benefits and the corresponding changes in the CDA set-size effect were absent with tPBM at a wavelength of 852 nm or with stimulation of the left PFC. Our findings provide converging evidence that 1064-nm tPBM applied to the right PFC can improve WM capacity.
经颅光生物调节（tPBM）是一种安全且无创的干预措施，已显示出改善认知表现的潜力。tPBM是否能调节大脑活动，从而增强人类的工作记忆（WM）能力仍不清楚。在本研究中，我们发现，应用于右侧前额叶皮层（PFC）的1064纳米tPBM可提高视觉工作记忆能力，并增加枕顶叶对侧延迟活动（CDA）。在保持期间的CDA集合大小效应介导了1064纳米tPBM与随后的WM能力之间的效应。在852纳米波长的tPBM或左侧PFC刺激下，行为益处以及CDA集合大小效应的相应变化均不存在。我们的研究结果提供了一致的证据，即应用于右侧PFC的1064纳米tPBM可提高WM能力。
