Bazin H, Platteau B
Immunology. 1976 May;30(5):679-84.
Reaginic antibody synthesis following parenteral and/or oral administration of ovalbumin and Bordetella pertussis organisms as adjuvant has been evaluated in LOU/M/Wsl inbred rats. These rats are able to produce high reaginic antibody serum levels after intraperitoneal injection of this antigen. Primary oral administration of ovalbumin doses between 10 and 100 mg with Bordetella pertussis organisms given as adjuvant by the intraperitoneal or the oral route led to characteristic reagnic responses. Secondary reaginic responses were obtained by oral administration of ovalbumin without any adjuvant in animals sensitized by the oral or the intraperitoneal route. A hundred micrograms of ovalbumin was enough to induce reaginic responses but more constant and higher reaginic levels were obtained with a 50 mg dose in the experimental model employed.
已在LOU/M/Wsl近交系大鼠中评估了经肠胃外和/或口服给予卵清蛋白以及作为佐剂的百日咳博德特氏菌后反应素抗体的合成情况。这些大鼠在腹腔注射该抗原后能够产生高反应素抗体血清水平。以腹腔内或口服途径给予百日咳博德特氏菌作为佐剂，初次口服10至100毫克剂量的卵清蛋白会引发特征性的反应素反应。在经口服或腹腔途径致敏的动物中，通过口服无任何佐剂的卵清蛋白获得二次反应素反应。在所用实验模型中，100微克卵清蛋白足以诱导反应素反应，但50毫克剂量可获得更稳定且更高的反应素水平。
