锌对细菌及其他细胞溶解剂诱导的溶血的抑制作用。
Inhibition by zinc of hemolysis induced by bacterial and other cytolytic agents.
作者信息
Avigad L S, Bernheimer A W
出版信息
Infect Immun. 1976 May;13(5):1378-81. doi: 10.1128/iai.13.5.1378-1381.1976.
Abstract
Zinc, cupric, and cadmium ions, in that order of effectiveness, inhibited lysis of washed, rabbit erythrocytes by the toxic bacterial product aerolysin. Hemolysis induced by a variety of other lytic agents was also inhibited by Zn2+ in approximately the same concentration as that, 0.33 mM, needed to inhibit aerolysin-induced hemolysis. Zinc ions did not inhibit osmotic lysis. Inhibition requires the continues presence of Zn2+ and apparently involves a readily reversible binding of Zn2+ to the cell surface, which, it is postulated is accompanied by a reversible alteration in the state of the lipid bilayer.
摘要
锌离子、铜离子和镉离子按有效程度依次抑制了有毒细菌产物气溶素对洗涤过的兔红细胞的溶解作用。多种其他裂解剂诱导的溶血也被锌离子抑制，其浓度与抑制气溶素诱导溶血所需的浓度大致相同，即0.33 mM。锌离子不抑制渗透裂解。抑制作用需要锌离子持续存在，显然涉及锌离子与细胞表面的易逆结合，据推测这伴随着脂质双层状态的可逆改变。
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