锌对细菌及其他细胞溶解剂诱导的溶血的抑制作用。
Inhibition by zinc of hemolysis induced by bacterial and other cytolytic agents.
作者信息
Avigad L S, Bernheimer A W
出版信息
Infect Immun. 1976 May;13(5):1378-81. doi: 10.1128/iai.13.5.1378-1381.1976.
Abstract
Zinc, cupric, and cadmium ions, in that order of effectiveness, inhibited lysis of washed, rabbit erythrocytes by the toxic bacterial product aerolysin. Hemolysis induced by a variety of other lytic agents was also inhibited by Zn2+ in approximately the same concentration as that, 0.33 mM, needed to inhibit aerolysin-induced hemolysis. Zinc ions did not inhibit osmotic lysis. Inhibition requires the continues presence of Zn2+ and apparently involves a readily reversible binding of Zn2+ to the cell surface, which, it is postulated is accompanied by a reversible alteration in the state of the lipid bilayer.
摘要
锌离子、铜离子和镉离子按有效程度依次抑制了有毒细菌产物气溶素对洗涤过的兔红细胞的溶解作用。多种其他裂解剂诱导的溶血也被锌离子抑制，其浓度与抑制气溶素诱导溶血所需的浓度大致相同，即0.33 mM。锌离子不抑制渗透裂解。抑制作用需要锌离子持续存在，显然涉及锌离子与细胞表面的易逆结合，据推测这伴随着脂质双层状态的可逆改变。
相似文献
1
Inhibition by zinc of hemolysis induced by bacterial and other cytolytic agents.锌对细菌及其他细胞溶解剂诱导的溶血的抑制作用。
Infect Immun. 1976 May;13(5):1378-81. doi: 10.1128/iai.13.5.1378-1381.1976.
2
Effect of zinc ion on the hemolytic activity of thermostable direct hemolysin from Vibrio parahaemolyticus, streptolysin O, and Triton X-100.锌离子对副溶血性弧菌耐热直接溶血素、链球菌溶血素O及曲拉通X-100溶血活性的影响。
Infect Immun. 1977 Aug;17(2):239-43. doi: 10.1128/iai.17.2.239-243.1977.
3
Inhibition of hemolysis by zinc and its reversal by L-histidine.锌对溶血的抑制作用及其被L-组氨酸逆转的情况。
Infect Immun. 1978 Mar;19(3):1101-3. doi: 10.1128/iai.19.3.1101-1103.1978.
4
Latent effects of haemolytic agents.溶血剂的潜在作用。
J Gen Microbiol. 1966 Aug;44(2):233-40. doi: 10.1099/00221287-44-2-233.
5
Metabolically controlled hemolysis of chicken erythrocytes.
Biochim Biophys Acta. 1973 Feb 16;291(3):690-700. doi: 10.1016/0005-2736(73)90474-4.
6
Inhibition of listeriolysin O-induced hemolysis by bovine lactoferrin.牛乳铁蛋白对李斯特菌溶血素O诱导的溶血作用的抑制
Biol Pharm Bull. 1999 Nov;22(11):1167-72. doi: 10.1248/bpb.22.1167.
7
Purification of Clostridium perfringens type C theta toxin.产气荚膜梭菌C型θ毒素的纯化
Can J Microbiol. 1973 Aug;19(8):881-5. doi: 10.1139/m73-141.
8
[The effect of Zn ions on erythrocyte hemolysis induced by melittin].[锌离子对蜂毒肽诱导的红细胞溶血的影响]
Biokhimiia. 1995 May;60(5):723-33.
9
Evidence for a one-hit theory in the immune bactericidal reaction and demonstration of a multi-hit response for hemolysis by streptolysin O and Clostridium perfringens theta-toxin.免疫杀菌反应中单次打击理论的证据以及链球菌溶血素O和产气荚膜梭菌θ毒素对溶血的多次打击反应的证明。
Infect Immun. 1976 Feb;13(2):337-44. doi: 10.1128/iai.13.2.337-344.1976.
10
Phenomenon of hot-cold hemolysis: chelator-induced lysis of sphingomyelinase-treated erythrocytes.冷热溶血现象：螯合剂诱导的经鞘磷脂酶处理的红细胞溶解
Infect Immun. 1975 Nov;12(5):1104-11. doi: 10.1128/iai.12.5.1104-1111.1975.
引用本文的文献
1
Morin Protects Channel Catfish From Infection by Blocking Aerolysin Activity.桑色素通过阻断气溶素活性保护斑点叉尾鮰免受感染。
Front Microbiol. 2018 Nov 21;9:2828. doi: 10.3389/fmicb.2018.02828. eCollection 2018.
2
Cubozoan venom-induced cardiovascular collapse is caused by hyperkalemia and prevented by zinc gluconate in mice.圆斑蝰蛇毒引起的心血管崩溃是由高钾血症引起的，可被葡萄糖酸锌预防。
PLoS One. 2012;7(12):e51368. doi: 10.1371/journal.pone.0051368. Epub 2012 Dec 12.
3
Relationships between metal ions and oxygen free radicals in ethanol-induced damage to cultured rat gastric mucosal cells.乙醇诱导的大鼠胃黏膜细胞损伤中金属离子与氧自由基的关系
Dig Dis Sci. 1995 Dec;40(12):2704-11. doi: 10.1007/BF02220463.
4
Triton channels are sensitive to divalent cations and protons.瞬时受体电位通道对二价阳离子和质子敏感。
J Membr Biol. 1994 Jul;141(1):83-90. doi: 10.1007/BF00232876.
5
Studies on rubescenslysin haemolysis.红溶素溶血研究。
Naunyn Schmiedebergs Arch Pharmacol. 1980 Feb;311(1):95-103. doi: 10.1007/BF00500309.
6
Histamine as a ligand in blood plasma. Part 5. Computer simulated distribution of metal histamine complexes in normal blood plasma and discussion of the implications of a possible role of zinc and copper in histamine catabolism.组胺作为血浆中的一种配体。第5部分。计算机模拟正常血浆中金属组胺络合物的分布以及锌和铜在组胺分解代谢中可能作用的影响讨论。
Agents Actions. 1982 Jul;12(3):398-407. doi: 10.1007/BF01965410.
7
Effect of calcium ions on staphylococcal alpha-toxin-induced hemolysis of rabbit erythrocytes.钙离子对葡萄球菌α毒素诱导兔红细胞溶血的影响。
Infect Immun. 1985 Jan;47(1):37-40. doi: 10.1128/iai.47.1.37-40.1985.
8
Purification and characterization of Vibrio metschnikovii cytolysin.米氏弧菌溶细胞素的纯化与特性分析
Infect Immun. 1988 Apr;56(4):954-60. doi: 10.1128/iai.56.4.954-960.1988.
9
Effects of divalent cations and saccharides on Vibrio metschnikovii cytolysin-induced hemolysis of rabbit erythrocytes.二价阳离子和糖类对梅氏弧菌溶细胞素诱导兔红细胞溶血的影响。
Infect Immun. 1989 Jan;57(1):158-63. doi: 10.1128/iai.57.1.158-163.1989.
10
Ion modulation of membrane permeability: effect of cations on intact cells and on cells and phospholipid bilayers treated with pore-forming agents.膜通透性的离子调节：阳离子对完整细胞以及对用成孔剂处理过的细胞和磷脂双层膜的影响。
J Membr Biol. 1988 Jul;103(1):79-94. doi: 10.1007/BF01871934.
本文引用的文献
1
Determination of human erythrocyte zinc: hemoglobin ratios.人体红细胞锌与血红蛋白比例的测定
Clin Chim Acta. 1962 Sep;7:634-8. doi: 10.1016/0009-8981(62)90142-0.
2
Isolation and composition of staphylococcal alpha toxin.葡萄球菌α毒素的分离与组成
J Gen Microbiol. 1963 Mar;30:455-68. doi: 10.1099/00221287-30-3-455.
3
The interaction of divalent metal ions with tris buffer in dilute solution.稀溶液中二价金属离子与三羟甲基氨基甲烷缓冲液的相互作用。
Anal Biochem. 1966 Aug;16(2):225-33. doi: 10.1016/0003-2697(66)90150-3.
4
The effect of zinc and other metals on the stability of lysosomes.锌及其他金属对溶酶体稳定性的影响。
Proc Soc Exp Biol Med. 1972 Jun;140(2):642-6. doi: 10.3181/00379727-140-36521.
5
The effect of zinc and other metals on complement hemolysis of sheep red blood cells in vitro.锌及其他金属对绵羊红细胞体外补体溶血的影响。
Proc Soc Exp Biol Med. 1974 Jan;145(1):263-7. doi: 10.3181/00379727-145-37789.
6
Staphylococcal sphingomyelinase (beta-hemolysin).葡萄球菌鞘磷脂酶（β-溶血素）
Ann N Y Acad Sci. 1974 Jul 31;236(0):292-306. doi: 10.1111/j.1749-6632.1974.tb41499.x.
7
Partial characterization of aerolysin, a lytic exotoxin from Aeromonas hydrophila.嗜水气单胞菌溶细胞外毒素气溶素的部分特性
Infect Immun. 1974 Jun;9(6):1016-21. doi: 10.1128/iai.9.6.1016-1021.1974.
8
Histamine release from mast cells by compound 48/80. The membrane action of zinc.化合物48/80诱导肥大细胞释放组胺。锌的膜作用。
Agents Actions. 1974 Dec;4(5):320-3. doi: 10.1007/BF01964934.
9
Inhibition of the terminal stage of complement-mediated lysis (reactive lysis) by zinc and copper ions.锌离子和铜离子对补体介导的细胞溶解终末阶段（反应性溶解）的抑制作用。
Int Arch Allergy Appl Immunol. 1975;48(5):653-63. doi: 10.1159/000231353.
Zotero 插件