Povazay Boris, Hofer Bernd, Hermann Boris, Unterhuber Angelika, Morgan James E, Glittenberg Carl, Binder Susanne, Drexler Wolfgang
Cardiff University, School of Optometry and Vision Sciences, Biomedical Imaging Group, Cardiff, Wales CF24 4LU, United Kingdom.
J Biomed Opt. 2007 Jul-Aug;12(4):041204. doi: 10.1117/1.2773736.
Objective imaging of the optic nerve structure has become central to the management of patients with glaucoma. There is an urgent need in diagnosis and staging for reliable objective precursors and markers. Three-dimensional ultrahigh-resolution frequency domain optical coherence tomography (3D UHR OCT) holds particular promise in this respect since it enables volumetric assessment of intraretinal layers including tomographic data for the retinal nerve fiber layer (RNFL) and optic nerve head. The integrated analysis of this information and the resolution advantage has enabled the development of more informative indices of axonal damage in glaucoma compared with measurements of RNFL thickness and cup-to-disc ratio provided by commercial OCT devices. The potential for UHR OCT in enabling the combined analysis of tomographic and volumetric data on retinal structure is explored. A novel parameter was developed; the three-dimensional minimal distance as the optical correlate of true retinal nerve fiber layer thickness around the optic nerve head region. For the purposes of this pilot study, we present data from a normal subject and from two patients with characteristic optic nerve and retinal nerve fiber layer changes secondary to glaucoma.
对视神经结构进行客观成像已成为青光眼患者治疗的核心。在诊断和分期方面，迫切需要可靠的客观先兆和标志物。三维超高分辨率频域光学相干断层扫描（3D UHR OCT）在这方面具有特殊的前景，因为它能够对视网膜内层进行容积评估，包括视网膜神经纤维层（RNFL）和视神经头的断层数据。与商业OCT设备提供的RNFL厚度和杯盘比测量相比，对这些信息的综合分析以及分辨率优势使得能够开发出更具信息量的青光眼轴突损伤指标。本文探讨了UHR OCT在对视网膜结构的断层和容积数据进行联合分析方面的潜力。开发了一个新参数；三维最小距离作为视神经头区域周围真实视网膜神经纤维层厚度的光学相关指标。在本初步研究中，我们展示了一名正常受试者以及两名因青光眼继发特征性视神经和视网膜神经纤维层改变的患者的数据。
