Jordan Jennifer, Joyce Peter R, Carter Frances A, Horn Jacqueline, McIntosh Virginia V W, Luty Suzanne E, McKenzie Janice M, Frampton Christopher M A, Mulder Roger T, Bulik Cynthia M
Department of Psychological Medicine, University of Otago, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand.
Int J Eat Disord. 2008 Jan;41(1):47-56. doi: 10.1002/eat.20463.
This article reports lifetime Axis I and II comorbidity in women with anorexia nervosa (AN), and ascertains specific and nonspecific comorbidity in AN compared to clinical samples of women with bulimia nervosa (BN) or major depression (DEP).
Outpatient AN (n = 56), BN (n = 132), and DEP (n = 100) samples were assessed using Structured Clinical Interviews I and II for DSM-III-R. Baseline data were compared using univariate statistics and logistic regression.
In the AN sample as a whole, specific elevations were found for prevalences of obsessive compulsive disorder. The AN-binge eating purging subtype (AN-BP) and the BN sample had elevated prevalences of Cluster B personality disorders. Cluster C prevalences were elevated across samples.
Evidence of AN-specific, eating disorder-specific, and nonspecific comorbidity illustrates the heterogeneity in AN. Further research is need to examine the relative impact of specific and nonspecific comorbidity in AN subtypes and AN as a whole.
本文报告神经性厌食症（AN）女性患者的终生轴I和轴II共病情况，并确定与神经性贪食症（BN）或重度抑郁症（DEP）女性临床样本相比，AN中的特异性和非特异性共病情况。
使用针对《精神疾病诊断与统计手册》第三版修订本（DSM-III-R）的结构化临床访谈I和II对门诊AN患者样本（n = 56）、BN患者样本（n = 132）和DEP患者样本（n = 100）进行评估。使用单变量统计和逻辑回归对基线数据进行比较。
在整个AN样本中，强迫症患病率有特异性升高。AN-暴食清除亚型（AN-BP）和BN样本中，B类人格障碍的患病率升高。C类人格障碍在所有样本中的患病率均升高。
AN特异性、饮食障碍特异性和非特异性共病的证据说明了AN的异质性。需要进一步研究以检查特异性和非特异性共病对AN亚型及整体AN的相对影响。
