健康人体受试者体内针对应激诱导的72 kDa蛋白（热休克蛋白hsp70家族成员）的特异性抗体。
Specific antibodies against the stress-inducible 72-kDa protein, a member of the heat-shock protein hsp70, in healthy human subjects.
作者信息
Wakui H, Itoh H, Tashima Y, Kobayashi R, Nakamoto Y, Miura A B
机构信息
Third Department of Internal Medicine, Akita University School of Medicine, Japan.
出版信息
Int J Biochem. 1991;23(10):975-8. doi: 10.1016/0020-711x(91)90132-7.
PMID:1786858
Abstract
- On Western blot analysis, serum IgG from a healthy human subject reacted with a stress-induced protein, having an apparent molecular mass of 70 kDa, from PC12 cells. 2. This serum IgG also reacted with hsp70 (70-kDa heat-shock protein) purified from the bovine brain. 3. In 5 out of 34 healthy human subjects, IgG antibodies against hsp70 were detected. 4. These antibodies were directed against the stress-inducible 72-kDa protein, but did not cross-react with the constitutive 73-kDa protein.
摘要
- 在蛋白质印迹分析中，来自健康人类受试者的血清IgG与PC12细胞中一种应激诱导蛋白发生反应，该蛋白的表观分子量为70 kDa。2. 这种血清IgG也与从牛脑中纯化的hsp70（70 kDa热休克蛋白）发生反应。3. 在34名健康人类受试者中，有5名检测到针对hsp70的IgG抗体。4. 这些抗体针对应激诱导的72 kDa蛋白，但不与组成型73 kDa蛋白发生交叉反应。
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