Mäntyselkä Pekka, Miettola Juhani, Niskanen Leo, Kumpusalo Esko
Family Practice Unit, University of Kuopio & Kuopio University Hospital, P.O. Box 1777, Kuopio FIN-70211, Finland Department of Medicine, Kuopio University Hospital, P.O. Box 1777, Kuopio FIN-70211, Finland.
Pain. 2008 Jul;137(1):34-40. doi: 10.1016/j.pain.2007.08.007. Epub 2007 Sep 14.
The aim of this study was to analyse how plasma glucose level and diabetes mellitus (DM) are associated with chronic pain in the adult population. A structured interview and health examination study with 480 participants aged 30-65 years was carried out in Lapinlahti municipality in Eastern Finland. Chronic pain (duration of at least 3 months) was graded according to frequency: being present less often than daily, or every day or continuously (daily chronic pain, DCP). Elevated plasma glucose was defined as a plasma glucose level 6.1 mmol/l. DM diagnosis was based on self-reported diagnoses, reimbursed medication or a health examination with laboratory tests. Glucose regulation status was defined according to fasting plasma glucose level and a two-hour glucose tolerance test. Of the total sample, 90 subjects (19%) had a plasma glucose level > or = 6.1 mmol/l and 55 subjects (11%) had diabetes. The prevalence of daily chronic pain was 21% (N = 101) in all the subjects. In the subjects with a normal plasma glucose level, the prevalence was 18%, while in those with an elevated plasma glucose level it was 38%. The corresponding percentages for non-diabetics and diabetics were 19% and 42%. In the multinomial multivariate logistic regression analysis, glucose level or diabetes was associated with DCP. The odds for DCP in the subjects with an elevated plasma glucose level was 2.37 (95% CI, 1.26-4.49), and in those with DM it was 2.53 (95% CI, 1.12-5.72). Elevated plasma glucose level and DM are associated with DCP in adults.
本研究旨在分析血浆葡萄糖水平和糖尿病（DM）与成年人群慢性疼痛之间的关联。在芬兰东部的拉彭兰塔市对480名年龄在30 - 65岁的参与者进行了结构化访谈和健康检查研究。慢性疼痛（持续时间至少3个月）根据频率分级：出现频率低于每日一次，或每天或持续出现（每日慢性疼痛，DCP）。血浆葡萄糖升高定义为血浆葡萄糖水平≥6.1 mmol/l。DM诊断基于自我报告的诊断、报销药物或实验室检查的健康检查。根据空腹血浆葡萄糖水平和两小时葡萄糖耐量试验定义血糖调节状态。在总样本中，90名受试者（19%）的血浆葡萄糖水平≥6.1 mmol/l，55名受试者（11%）患有糖尿病。所有受试者中每日慢性疼痛的患病率为21%（N = 101）。血浆葡萄糖水平正常的受试者中患病率为18%，而血浆葡萄糖水平升高的受试者中患病率为38%。非糖尿病患者和糖尿病患者的相应百分比分别为19%和42%。在多项多变量逻辑回归分析中，葡萄糖水平或糖尿病与DCP相关。血浆葡萄糖水平升高的受试者中DCP的比值比为2.37（95%置信区间，1.26 - 4.49），患有DM的受试者中比值比为2.53（95%置信区间，1.12 - 5.72）。血浆葡萄糖水平升高和DM与成年人的DCP相关。
