Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico, and General Hospital, Secretary of Health, Durango, Mexico.
Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico, and General Hospital, Secretary of Health, Durango, Mexico.
Arch Med Res. 2014 Jan;45(1):70-5. doi: 10.1016/j.arcmed.2013.11.004. Epub 2013 Dec 8.
Several studies show that high serum C-reactive protein (CRP) levels are associated with an increased risk of diabetes, data that strongly supports a possible role for inflammation in diabetogenesis. The aim of this study was to determine whether elevated CRP levels are associated with fasting plasma glucose (FPG) and/or postload glucose levels according to the glucose tolerance status.
A total of 169 healthy males and non-pregnant females aged 18-65 years were enrolled in a population-based cross-sectional study. Individuals were allocated into groups with a new diagnosis of normal glucose tolerance (NGT) (n = 82), impaired fasting glucose (IFG) (n = 54), and impaired glucose tolerance (IGT) (n = 33). Elevated CRP was defined by CRP levels >3.0 and <10.0 mg/L, IFG by FPG ≥100 and <126 mg/dL, and IGT by plasma glucose concentration 2 h postload ≥140 and <200 mg/dL. A multiple regression linear analysis adjusted by body mass index, waist circumference, and lipid profile was performed to evaluate the association between CRP levels (independent variable) with FPG and 2 h postload glucose levels (dependent variables).
Multivariate linear regression analysis showed a significant association between hsCRP levels with FPG (β = 0.536; 95% CI 1.03-5.1, p = 0.005) and 2 h postload glucose (β = 0.209; 95% CI 1.31-2.97, p = 0.01) in the IGT group, but not with FPG (β = 0.147; 95% CI 0.55-2.0, p = 0.25) and 2 h postload glucose (β = 0.151; 95% CI 0.83-3.2, p = 0.24) in the IFG group.
Elevated CRP levels are associated with FPG and 2 h postload glucose in the individuals with IGT, but not in subjects with IFG or NGT.
多项研究表明，高血清 C 反应蛋白（CRP）水平与糖尿病风险增加相关，这些数据强烈支持炎症在糖尿病发生中的可能作用。本研究旨在根据葡萄糖耐量状态，确定 CRP 水平升高是否与空腹血糖（FPG）和/或负荷后血糖水平相关。
本研究共纳入了 169 名年龄在 18-65 岁之间的健康男性和非妊娠女性，进行了一项基于人群的横断面研究。根据新诊断的正常糖耐量（NGT）（n=82）、空腹血糖受损（IFG）（n=54）和糖耐量受损（IGT）（n=33）将个体分为不同的组别。CRP 升高定义为 CRP 水平>3.0 和<10.0mg/L，IFG 定义为 FPG≥100 和<126mg/dL，IGT 定义为负荷后 2 小时血糖浓度≥140 和<200mg/dL。采用多元线性回归分析，对 CRP 水平（自变量）与 FPG 和负荷后 2 小时血糖水平（因变量）进行调整，以评估两者之间的相关性。
多变量线性回归分析显示，hsCRP 水平与 IGT 组的 FPG（β=0.536；95%CI 1.03-5.1，p=0.005）和负荷后 2 小时血糖（β=0.209；95%CI 1.31-2.97，p=0.01）显著相关，但与 IFG 组的 FPG（β=0.147；95%CI 0.55-2.0，p=0.25）和负荷后 2 小时血糖（β=0.151；95%CI 0.83-3.2，p=0.24）不相关。
在 IGT 患者中，CRP 水平升高与 FPG 和负荷后 2 小时血糖相关，但在 IFG 或 NGT 患者中则不然。
