Guggenbuhl Pascal, Chappard Daniel, Garreau Mireille, Bansard Jean-Yves, Chales Gérard, Rolland Yan
INSERM, U642, LTSI, Campus Beaulieu, Bat 22, 35042 Rennes Cédex, France.
Eur J Radiol. 2008 Sep;67(3):514-20. doi: 10.1016/j.ejrad.2007.08.003. Epub 2007 Sep 14.
Bone microarchitecture is an important determinant of the fracture risk, independently of bone mineral density. At present, bone biopsy is required for microarchitecture assessment, and accessible non-invasive techniques are needed. In this study, we tested the short-term reproducibility and parameter changes of a non-invasive method for microarchitecture assessment with a medical computed tomography. Texture parameters (run lengths and co-occurrence) were extracted from bone sample images. Reproducibility and the influence of slice thickness (1, 3, 5 and 8mm) were also studied. After five repositionings, short-term reproducibility was found to be good. All run length parameters but one fell significantly with increasing slice thickness. Co-occurrence parameters showed different patterns of change. Short-term coefficients of variation of texture parameters used to assess bone microarchitecture were similar to those obtained elsewhere with other techniques. The results were influenced by slice thicknesses, emphasizing the importance of the conditions of acquisition.
骨微结构是骨折风险的重要决定因素，与骨矿物质密度无关。目前，骨微结构评估需要进行骨活检，因此需要可及的非侵入性技术。在本研究中，我们测试了一种使用医学计算机断层扫描进行骨微结构评估的非侵入性方法的短期可重复性和参数变化。从骨样本图像中提取纹理参数（游程长度和共生矩阵）。还研究了切片厚度（1、3、5和8毫米）的可重复性及其影响。经过五次重新定位后，发现短期可重复性良好。除一个游程长度参数外，所有游程长度参数均随切片厚度增加而显著下降。共生矩阵参数呈现出不同的变化模式。用于评估骨微结构的纹理参数的短期变异系数与其他技术在其他地方获得的结果相似。结果受切片厚度的影响，强调了采集条件的重要性。
