Vanichseni S, Wongsuwan B, Choopanya K, Wongpanich K
Drug Abuse Prevention and Treatment Division, Bangkok Metropolitan Administration, Thailand.
Int J Addict. 1991 Dec;26(12):1313-20. doi: 10.3109/10826089109062163.
This study represents the first controlled trial of methadone maintenance and 45-day methadone detoxification in Thailand. We randomly assigned 240 male heroin addicts with at least six prior detoxification treatment episodes to 45-day detoxification or to methadone maintenance treatment conditions. We found that methadone maintenance clients were more likely to complete 45 days of treatment (p less than .00001), were less likely to have used heroin during treatment (p less than .0002), and were less likely to have used heroin on the 45th day of treatment (p less than .000007). These findings are consistent with the results of other studies in the United States, and we conclude that methadone maintenance could be a significant adjunct to AIDS prevention efforts for intravenous drug users in Thailand.
本研究是泰国首次针对美沙酮维持治疗及45天美沙酮脱毒治疗的对照试验。我们将240名至少有过6次戒毒治疗经历的男性海洛因成瘾者随机分为接受45天脱毒治疗组或美沙酮维持治疗组。我们发现，接受美沙酮维持治疗的患者更有可能完成45天的治疗（p小于0.00001），在治疗期间使用海洛因的可能性更小（p小于0.0002），且在治疗第45天使用海洛因的可能性更小（p小于0.000007）。这些发现与美国其他研究的结果一致，我们得出结论：美沙酮维持治疗可能是泰国预防静脉吸毒者感染艾滋病的一项重要辅助措施。
