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在植入颅内电极的自由活动猫身上的P300

P300 in freely moving cats with intracranial electrodes.

作者信息

Başar-Eroglu C, Başar E, Schmielau F

机构信息

Institute of Medical Psychology, Medical University, Lübeck, Germany.

出版信息

Int J Neurosci. 1991 Oct;60(3-4):215-26. doi: 10.3109/00207459109167034.

DOI:10.3109/00207459109167034
PMID:1787050
Abstract

Nine chronically implanted cats were used in order to study the event related potentials (ERPs) of the brain with the "omitted stimulus" paradigm. The cats were not restrained and not conditioned, could behave freely in a soundfree room. Due to a selective averaging method a P300 like of response component could be detected in the hippocampus, auditory cortex and reticular formation. The most robust and ample component was the N200-P300 wave complex of the hippocampus. The results are interpreted as follows: the P300 component in the cat brain has probably distributed generators with various frequency selectivities. The hippocampal ERP has a strong theta response component, whereas the auditory cortex and reticular formation have more marked 10 Hz responses.

摘要

为了使用“遗漏刺激”范式研究大脑的事件相关电位(ERP),我们使用了9只长期植入电极的猫。这些猫没有受到限制,也没有经过条件训练,可以在隔音室中自由活动。由于采用了选择性平均法,在海马体、听觉皮层和网状结构中可以检测到类似P300的反应成分。最强烈且丰富的成分是海马体的N200 - P300波复合体。结果如下解释:猫脑中的P300成分可能具有分布广泛的、具有不同频率选择性的发生器。海马体ERP有强烈的θ反应成分,而听觉皮层和网状结构有更明显的10Hz反应。

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