Rashid Harunor, Shafi Shuja, Haworth Elizabeth, El Bashir Haitham, Ali Kamal A, Memish Ziad A, Booy Robert
Academic Unit of Child Health, Queen Mary University of London, UK.
Travel Med Infect Dis. 2007 Sep;5(5):310-3. doi: 10.1016/j.tmaid.2007.07.006. Epub 2007 Sep 6.
Muslim pilgrims going on the Hajj are at risk of influenza. The treatment and prevention of influenza with antiviral drugs depends on rapid diagnosis using a near-patient test such as the QuickVue influenza test. The suitability of this test among pilgrims has not been studied in the past and this study assesses the usefulness of the test for diagnosing influenza among those attending the Hajj.
The sensitivity and specificity of the QuickVue test were measured against reverse transcriptase polymerase chain reaction by undertaking the tests on nasal swab samples from pilgrims.
The sensitivity and specificity of the QuickVue test were 22% and 99%, respectively, and its likelihood ratio for a positive and a negative test were 22 and 0.79 in that order.
The QuickVue influenza test using nasal swabs is poorly sensitive for diagnosing influenza among Hajj pilgrims. Given its high specificity and an even higher likelihood ratio for a positive test it may still be a very useful tool for influenza surveillance at the Hajj.
前往麦加朝觐的穆斯林朝圣者有感染流感的风险。使用如QuickVue流感检测等即时检验手段进行快速诊断，是流感抗病毒药物治疗与预防的关键。过往尚未对该检测在朝圣者中的适用性展开研究，本研究旨在评估此检测手段对朝觐者流感诊断的有效性。
通过对朝圣者鼻拭子样本进行检测，以逆转录聚合酶链反应作为对照，测定QuickVue检测的敏感性和特异性。
QuickVue检测的敏感性和特异性分别为22%和99%，其阳性和阴性检测的似然比依次为22和0.79。
使用鼻拭子的QuickVue流感检测在诊断朝觐朝圣者流感方面敏感性欠佳。鉴于其高特异性以及更高的阳性检测似然比，它在朝觐期间的流感监测中或许仍是一项非常有用的工具。
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