Simmerman James Mark, Chittaganpitch Malinee, Erdman Dean, Sawatwong Pongpun, Uyeki Timothy M, Dowell Scott F
World Health Organization, 63 Tran Hung Dao Street, Hanoi, Vietnam.
Int J Infect Dis. 2007 Mar;11(2):166-71. doi: 10.1016/j.ijid.2006.01.005. Epub 2006 Jun 23.
Rapid influenza tests are increasingly used in surveillance systems and for clinical care in Southeast Asia. However, the performance and utility of rapid influenza tests under field conditions in rural Southeast Asia has not been evaluated.
In the context of a larger study on the causes of respiratory illness in rural Thailand, we used a rapid test to collect data on influenza burden, seasonality, and cost of illness. We compared the performance of the QuickVue Influenza Test to tissue cell viral culture and reverse transcriptase-polymerase chain reaction (RT-PCR) among 1092 Thai patients meeting the World Health Organization case definition for influenza-like illness over a 12-month period.
The sensitivity and specificity of the QuickVue test compared to viral culture were 77% and 96%, respectively. Rapid influenza tests were useful to describe the seasonality of influenza, estimate the cost of illness, increase the sensitivity of surveillance, conduct outbreak responses, and guide evaluation of suspected avian influenza virus infections.
Despite their high cost, rapid influenza diagnostic tests are useful tools for influenza research, surveillance, and outbreak investigations in Southeast Asia.
快速流感检测在东南亚的监测系统及临床医疗中使用得越来越频繁。然而，快速流感检测在东南亚农村地区现场条件下的性能和效用尚未得到评估。
在一项关于泰国农村地区呼吸道疾病病因的更大规模研究中，我们使用快速检测来收集有关流感负担、季节性和疾病成本的数据。在12个月期间，我们对1092名符合世界卫生组织流感样疾病病例定义的泰国患者，比较了QuickVue流感检测与组织细胞病毒培养及逆转录聚合酶链反应（RT-PCR）的性能。
与病毒培养相比，QuickVue检测的灵敏度和特异性分别为77%和96%。快速流感检测有助于描述流感的季节性、估计疾病成本、提高监测的灵敏度、开展疫情应对以及指导对疑似禽流感病毒感染的评估。
尽管成本高昂，但快速流感诊断检测仍是东南亚流感研究、监测和疫情调查的有用工具。
