11种抗肺炎球菌抗生素通过多步和单步方法选择耐药性的能力。
Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies.
作者信息
Clark Catherine L, Kosowska-Shick Klaudia, Ednie Lois M, Appelbaum Peter C
机构信息
Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
出版信息
Antimicrob Agents Chemother. 2007 Nov;51(11):4196-201. doi: 10.1128/AAC.00827-07. Epub 2007 Sep 17.
Abstract
Testing of 12 pneumococcal strains with differing resistotypes [including tet(M) positive] showed that tigecycline, amoxicillin-clavulanate, imipenem, and ceftriaxone did not select for resistant clones after 50 sequential subcultures. By comparison, azithromycin, clarithromycin, clindamycin, telithromycin, levofloxacin, moxifloxacin, and gemifloxacin did show resistant clones. Tigecycline also yielded a low frequency of resistance in single-step tests compared to all beta-lactams, macrolides/ketolides, and quinolones tested.
摘要
对12株具有不同耐药类型（包括tet(M)阳性）的肺炎球菌菌株进行测试，结果显示，在连续传代50次后，替加环素、阿莫西林-克拉维酸、亚胺培南和头孢曲松未筛选出耐药克隆。相比之下，阿奇霉素、克拉霉素、克林霉素、泰利霉素、左氧氟沙星、莫西沙星和吉米沙星确实出现了耐药克隆。与所有测试的β-内酰胺类、大环内酯类/酮内酯类和喹诺酮类药物相比，替加环素在单步测试中也产生了低频率的耐药性。
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