抗菌剂对细胞内肺炎球菌的活性。
Activities of antimicrobial agents against intracellular pneumococci.
作者信息
Mandell G L, Coleman E J
机构信息
Division of Infectious Diseases, University of Virginia Health Systems, Charlottesville 22908, USA.
出版信息
Antimicrob Agents Chemother. 2000 Sep;44(9):2561-3. doi: 10.1128/AAC.44.9.2561-2563.2000.
Abstract
Pneumococci can enter and survive inside human lung alveolar carcinoma cells. We examined the activity of azithromycin, gentamicin, levofloxacin, moxifloxacin, penicillin G, rifampin, telithromycin, and trovafloxacin against pneumococci inside and outside cells. We found that moxifloxacin, trovafloxacin, and telithromycin were the most active, but only telithromycin killed all intracellular organisms.
摘要
肺炎球菌可进入人肺腺癌细胞并在其中存活。我们检测了阿奇霉素、庆大霉素、左氧氟沙星、莫西沙星、青霉素G、利福平、泰利霉素和曲伐沙星对细胞内外肺炎球菌的活性。我们发现莫西沙星、曲伐沙星和泰利霉素活性最强，但只有泰利霉素能杀死所有细胞内的细菌。
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