Wolf S, Pöstgens H, Bertram B, Schulte K, Teping C, Reim M
Augenklinik der Med. Fak. der RWTH Aachen.
Klin Monbl Augenheilkd. 1991 Nov;199(5):325-9. doi: 10.1055/s-2008-1046089.
The hemodynamic status of 26 patients with retinitis pigmentosa was examined using video fluorescein angiography. The hemorheological parameters hematocrit, plasma viscosity, erythrocyte aggregation and erythrocyte rigidity were determined. The results were compared to a matched pairs-group. Video angiography showed for retinitis pigmentosa patients a normal arm-retina time and a significant increase of the arteriovenous passage time. The rheological parameters for both groups were within the reference range. Interestingly the hemodynamic disturbance of microcirculation could be demonstrated already in early stages with no ophthalmoscopic symptoms and no atrophy of retinal vessels detectable at the time. The results indicate that disturbance of the retinal hemodynamics in early stages of retinitis pigmentosa may play a role in the pathogenesis of the disease.
采用视频荧光血管造影术对26例色素性视网膜炎患者的血流动力学状态进行了检查。测定了血液流变学参数，包括血细胞比容、血浆粘度、红细胞聚集和红细胞刚性。将结果与配对对照组进行比较。视频血管造影显示，色素性视网膜炎患者的手臂-视网膜时间正常，动静脉通过时间显著延长。两组的流变学参数均在参考范围内。有趣的是，在早期阶段就可以证明存在微循环血流动力学紊乱，此时尚无检眼镜症状，也未检测到视网膜血管萎缩。结果表明，色素性视网膜炎早期视网膜血流动力学紊乱可能在该疾病的发病机制中起作用。
