Lopez-Heredia M A, Goyenvalle E, Aguado E, Pilet P, Leroux C, Dorget M, Weiss P, Layrolle P
INSERM, U791, Laboratoire d'ingénierie ostéoarticulaire et dentaire, Faculté de chirurgie dentaire, Université de Nantes, 1 Place Alexis Ricordeau, 44042 Nantes, France.
J Biomed Mater Res A. 2008 Jun 1;85(3):664-73. doi: 10.1002/jbm.a.31468.
Two porous titanium implants with a pore size diameter of 800 and 1200 microm (Ti800 and Ti1200) and an interconnected network were manufactured using rapid prototyping. Their dimensions and structure matched those of the computer assisted design. The porosity of the implants was around 60%. Their compressive strength and Young's modulus were around 80 MPa and 2.7 GPa, respectively. These values are comparable to those of cortical bone. The implants were implanted bilaterally in the femoral epiphysis of 15 New Zealand White rabbits. After 3 and 8 weeks, abundant bone formation was found inside the rapid prototyped porous titanium implants. For the Ti1200 implants, bone ingrowth was (23.9 +/- 3.5)% and (10.3 +/- 2.8)%, respectively. A significant statistical difference (p < 0.05) was found for bone ingrowth in the Ti1200 between the two delays. The percentage of bone directly apposited on titanium was (35.8 +/- 5.4)% and (30.5 +/- 5.0)%. No significant difference was found for bone-implant contact between the different time periods and pore sizes. This work demonstrates that manufacturing macroporous titanium implants with controlled shape and porosity using a rapid prototyping method is possible and that this technique is a good candidate for orthopedic and maxillofacial applications.
使用快速成型技术制造了两种孔径分别为800微米和1200微米的多孔钛植入物（Ti800和Ti1200），且具有相互连接的网络结构。它们的尺寸和结构与计算机辅助设计的相符。植入物的孔隙率约为60%。它们的抗压强度和杨氏模量分别约为80兆帕和2.7吉帕。这些值与皮质骨的值相当。将这些植入物双侧植入15只新西兰白兔的股骨骨骺中。3周和8周后，在快速成型的多孔钛植入物内部发现大量骨形成。对于Ti1200植入物，骨长入分别为（23.9±3.5）%和（10.3±2.8）%。在两个时间点之间，Ti1200的骨长入存在显著统计学差异（p<0.05）。直接附着在钛上的骨百分比为（35.8±5.4）%和（30.5±5.0）%。不同时间段和孔径之间的骨-植入物接触未发现显著差异。这项工作表明，使用快速成型方法制造具有可控形状和孔隙率的大孔钛植入物是可行的，并且该技术是骨科和颌面应用的良好候选方法。
