Basrani Bettina R, Manek Sheela, Sodhi Rana N S, Fillery Edward, Manzur Aldo
Department of Endodontics University of Toronto, Toronto, Ontario, Canada.
J Endod. 2007 Aug;33(8):966-9. doi: 10.1016/j.joen.2007.04.001. Epub 2007 May 18.
The combination of sodium hypochlorite (NaOCl) and chlorhexidine (CHX) results in the formation of a precipitate. The aim of this study was to determine the minimum concentration of NaOCl required to form a precipitate with 2.0% CHX. This was accomplished with a serial dilution technique. X-ray photon spectroscopy (XPS) and time-of-flight secondary ion mass spectrometry (TOF-SIMS) were used to qualify and quantify the precipitate. A color change and precipitate were induced in 2.0% CHX by 0.023% and 0.19% NaOCl, respectively. Both XPS and TOF-SIMS showed the presence of para-chloroaniline in an amount directly related to the concentration of NaOCl used. Until this precipitate is studied further, its formation should be avoided by removing the NaOCl before placing CHX into the canal.
次氯酸钠（NaOCl）与氯己定（CHX）混合会产生沉淀。本研究的目的是确定与2.0% CHX形成沉淀所需的NaOCl最低浓度。这是通过系列稀释技术完成的。采用X射线光子能谱（XPS）和飞行时间二次离子质谱（TOF-SIMS）对沉淀进行定性和定量分析。分别用0.023%和0.19%的NaOCl在2.0% CHX中诱导出颜色变化和沉淀。XPS和TOF-SIMS均显示对氯苯胺的存在量与所用NaOCl的浓度直接相关。在对该沉淀进行进一步研究之前，应在将CHX放入根管之前去除NaOCl以避免其形成。
