Donders Jacobus, Warschausky Seth
Psychology Service, Mary Free Bed Rehabilitation Hospital, Grand Rapids, MI 49503, USA.
J Head Trauma Rehabil. 2007 Sep-Oct;22(5):296-302. doi: 10.1097/01.HTR.0000290974.01872.82.
To examine differences in outcomes at transition age (17-21 years) between individuals who sustained complicated mild-to-severe traumatic brain injury (TBI) in early or middle childhood and those who were injured in late adolescence.
Fifteen persons who sustained TBI between the ages of 6 and 12 years (early-onset) and 30 persons who sustained TBI between the ages of 16 and 20 years (late-onset).
Peabody Picture Vocabulary Test-Third Edition, Trail-Making Test, Buschke Selective Reminding Test, Benton Visual Retention Test, Dysexecutive Questionnaire, Community Integration Questionnaire, Satisfaction with Life Scale.
The groups did not differ in overall cognitive ability level, postinjury education or vocational accomplishments, or current living situation. However the early-onset group demonstrated worse outcomes in higher-level cognitive skills, social integration, driving, and legal guardianship.
Complicated mild-to-severe TBI earlier in childhood is associated with worse long-term neurocognitive and psychosocial outcomes than injury sustained in late adolescence. Findings provide further support for theories that early brain injury onset interferes with development of immature or rapidly developing skills, and may be associated with further magnification of deficits during the course of later development.
研究在儿童早期或中期遭受复杂的轻至重度创伤性脑损伤（TBI）的个体与在青少年晚期受伤的个体在过渡年龄（17 - 21岁）时的结局差异。
15名在6至12岁之间遭受TBI的个体（早发组）和30名在16至20岁之间遭受TBI的个体（晚发组）。
皮博迪图片词汇测验第三版、连线测验、布施克选择性提醒测验、本顿视觉保持测验、执行功能障碍问卷、社区融入问卷、生活满意度量表。
两组在总体认知能力水平、伤后教育或职业成就以及当前生活状况方面没有差异。然而，早发组在高级认知技能、社会融入、驾驶和法律监护方面的结局更差。
儿童期早期遭受的复杂轻至重度TBI比青少年晚期遭受的损伤与更差的长期神经认知和心理社会结局相关。研究结果为早期脑损伤发病会干扰未成熟或快速发展技能的发育这一理论提供了进一步支持，并且可能与后期发育过程中缺陷的进一步放大有关。
