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来自杏的黄酮苷及其粗提物的抗菌活性。

Flavonoid glycosides from Prunus armeniaca and the antibacterial activity of a crude extract.

作者信息

Rashid Fahima, Ahmed Rehana, Mahmood Azhar, Ahmad Zaheer, Bibi Nazia, Kazmi Shahana Urooj

机构信息

Department of Chemistry, Faculty of Science, University of Karachi, Karachi, Pakistan.

出版信息

Arch Pharm Res. 2007 Aug;30(8):932-7. doi: 10.1007/BF02993959.

DOI:10.1007/BF02993959
PMID:17879744
Abstract

Investigations on the chemical constituents of the fruits of Prunus armeniaca have led to the isolation of two new flavonoid glycosides, 4',5,7-trihydroxy flavone-7-O-[beta-D-mannopyranosyl (1'''-->2")]-beta-D-allopyranoside (1) and 3,4',5,7-tetrahydroxy-3',5'-di-methoxy flavone 3-O-[alpha-L-rhamnopyranosyl (1'''-->6")]-beta-D-galactopyranoside (2), from the butanolic fraction of the fruits. The butanolic extract exhibited antibacterial activity against both Gram positive and Gram negative bacteria. The structures of these compounds were elucidated through spectral studies, including 2D-NMR (COSY, NOESY, J-resolved), HMQC and HMBC experiments.

摘要

对杏果实化学成分的研究导致从果实的正丁醇部分分离出两种新的黄酮苷,4',5,7-三羟基黄酮-7-O-[β-D-甘露吡喃糖基(1'''→2")]-β-D-阿洛吡喃糖苷(1)和3,4',5,7-四羟基-3',5'-二甲氧基黄酮3-O-[α-L-鼠李吡喃糖基(1'''→6")]-β-D-吡喃半乳糖苷(2)。正丁醇提取物对革兰氏阳性菌和革兰氏阴性菌均表现出抗菌活性。这些化合物的结构通过光谱研究得以阐明,包括二维核磁共振(COSY、NOESY、J-分解)、HMQC和HMBC实验。

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