Gomaa Amal H A, Yaar Mina, Eyada Moustafa M K, Bhawan Jag
Dermatopathology Section, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118, USA.
J Cutan Pathol. 2007 Oct;34(10):748-53. doi: 10.1111/j.1600-0560.2006.00695.x.
Our study evaluated the expression of vascular endothelial growth factor (VEGF), CD31 and D2-40 in involved and uninvolved skin of 18 patients with rosacea.
Immunostaining of facial skin specimens with VEGF, CD31 and D2-40 was compared between the lesional and the non-lesional skin of patients with erythemotelangiectatic and papulopustular rosacea.
Significantly increased dermal expression of VEGF in lesional vs. non-lesional skin (88.9% and 55.6%) was observed. Dermal expression of CD31 and D2-40 was also increased in lesional vs. non-lesional skin. There was no statistically significant difference in cutaneous expression of VEGF, CD31 and D2-40 between patients with papulopustular and erythemotelangiectatic rosacea, and no correlation was found between disease duration and immunoreactivity of VEGF, CD31or D2-40.
Our study showed marked immunostaining of lesional skin with VEGF, CD31 and D2-40 compared with non-lesional skin. Increased immunoreactivity of D2-40 in lesional skin is interesting, given that none of the patients had facial edema. There are no published data regarding the role of lymphangiogenesis in patients with non-phymatous rosacea; thus, our study represents a new understanding of its pathogenesis. Lack of correlation between D2-40 expression and disease duration suggests that lymphatics are involved early in the pathogenesis of rosacea and do not constitute a late event.
我们的研究评估了18例酒渣鼻患者受累皮肤和未受累皮肤中血管内皮生长因子（VEGF）、CD31和D2-40的表达情况。
比较了红斑毛细血管扩张型和丘疹脓疱型酒渣鼻患者皮损和非皮损面部皮肤标本中VEGF、CD31和D2-40的免疫染色情况。
观察到皮损皮肤中VEGF的真皮表达显著高于非皮损皮肤（分别为88.9%和55.6%）。皮损皮肤中CD31和D2-40的真皮表达也增加。丘疹脓疱型和红斑毛细血管扩张型酒渣鼻患者皮肤中VEGF、CD31和D2-40的表达无统计学显著差异，且未发现病程与VEGF、CD31或D2-40免疫反应性之间存在相关性。
我们的研究表明，与非皮损皮肤相比，皮损皮肤中VEGF、CD31和D2-40有明显的免疫染色。鉴于所有患者均无面部水肿，皮损皮肤中D2-40免疫反应性增加很有意思。关于淋巴管生成在非肥大性酒渣鼻患者中的作用，尚无已发表的数据；因此，我们的研究代表了对其发病机制的新认识。D2-40表达与病程缺乏相关性表明，淋巴管在酒渣鼻发病机制中早期就已受累，并非晚期事件。
