Vivantes-Klinikum Neukoelln, Klinik für Anaesthesie, operative Intensivmedizin und Schmerztherapie, Rudower Strasse 48, D-12313 Berlin, Germany.
Curr Infect Dis Rep. 2007 Sep;9(5):374-81. doi: 10.1007/s11908-007-0058-4.
The development of organ failure determines the course and prognosis of the septic patient. Although several successful clinical trials in recent years have raised the enthusiasm of intensivists, severe sepsis and septic shock still have an increasing incidence with more or less unchanged mortality. Recent sepsis research, including progress made in definitions, epidemiology, pathophysiology, diagnosis, standard and adjunctive therapy, and experimental approaches, is encouraging. This includes genomic information for stratifying subgroups of patients, a broader field of laboratory diagnostics due to clinical studies, and basic research on the cellular mechanisms of inflammation and organ dysfunction. Furthermore, new findings in pathogenesis and therapeutic approaches to organ failure merit attention. In this review, state-of-the-art publications are presented to elucidate the possible impact of sepsis-induced organ failure on clinical routine.
器官衰竭的发展决定了脓毒症患者的病程和预后。尽管近年来几项成功的临床试验提高了重症监护医生的积极性，但严重脓毒症和脓毒性休克的发病率仍在上升，死亡率或多或少没有变化。最近的脓毒症研究，包括在定义、流行病学、病理生理学、诊断、标准和辅助治疗以及实验方法方面取得的进展，令人鼓舞。这包括用于对患者亚组进行分层的基因组信息、由于临床研究而扩大的实验室诊断领域，以及关于炎症和器官功能障碍的细胞机制的基础研究。此外，关于器官衰竭发病机制和治疗方法的新发现值得关注。在这篇综述中，呈现了最新的文献，以阐明脓毒症引起的器官衰竭对临床常规可能产生的影响。
