莫洛尼C型病毒的缺失图谱：不同转化病毒分离株中的多肽和核酸表达
Deletion mapping of moloney type C virus: polypeptide and nucleic acid expression in different transforming virus isolates.
作者信息
Parks W P, Howk R S, Anisowicz A, Scolnick E M
出版信息
J Virol. 1976 May;18(2):491-503. doi: 10.1128/JVI.18.2.491-503.1976.
Abstract
The viral polypeptides and viral RNA present in cells transformed by various replication-defective type C viruses derived from Maloney murine leukemia virus were examined. Different portions of the Maloney type C viral genome were retained in the different transforming viruses, thus providing an opportunity for deletion mapping of the Moloney type C genome. DNA transcripts were prepared that are complementary to three distinct nonoverlapping portions of the Moloney viral geonome. Based on an anlysis of the polypeptides produced in the different transformed cells, one complementary DNA apparently respresents sequences coding for Moloney gp70; one complementary DNA represents a region of the Moloney genome common to all of the transforming viruses examined, and one complementary DNA represents the sequences for p30, p15, p10,12. A partial map of the different replication-defective transforming viruses is suggested.
摘要
对由源自莫洛尼鼠白血病病毒的各种复制缺陷型C型病毒转化的细胞中存在的病毒多肽和病毒RNA进行了检测。莫洛尼C型病毒基因组的不同部分保留在不同的转化病毒中，从而为莫洛尼C型基因组的缺失定位提供了机会。制备了与莫洛尼病毒基因组三个不同的非重叠部分互补的DNA转录本。基于对不同转化细胞中产生的多肽的分析，一个互补DNA显然代表编码莫洛尼gp70的序列；一个互补DNA代表所有检测的转化病毒共有的莫洛尼基因组区域，一个互补DNA代表p30、p15、p10、12的序列。提出了不同复制缺陷型转化病毒的部分图谱。
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