核糖体过滤器再探讨。
The ribosome filter redux.
作者信息
Mauro Vincent P, Edelman Gerald M
机构信息
Department of Neurobiology, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, La Jolla, California 92037, USA.
出版信息
Cell Cycle. 2007 Sep 15;6(18):2246-51. doi: 10.4161/cc.6.18.4739. Epub 2007 Jun 29.
Abstract
The ribosome filter hypothesis postulates that ribosomes are not simply translation machines but also function as regulatory elements that differentially affect or filter the translation of particular mRNAs. On the basis of new information, we take the opportunity here to review the ribosome filter hypothesis, suggest specific mechanisms of action, and discuss recent examples from the literature that support it.
摘要
核糖体筛选假说假定核糖体不仅是翻译机器，还作为调控元件发挥作用，对特定mRNA的翻译产生不同影响或进行筛选。基于新的信息，我们借此机会在此回顾核糖体筛选假说，提出具体的作用机制，并讨论文献中支持该假说的最新实例。
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