Department of Cornea and Refractive Surgery, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Cornea. 2020 Feb;39(2):258-262. doi: 10.1097/ICO.0000000000002155.
To assess the efficacy and safety of combined intracameral sulfur hexafluoride and full-thickness corneal sutures in the treatment of acute corneal hydrops (CH).
This is an uncontrolled series of cases with keratoconus (KC), keratoglobus (KG), and pellucid marginal degeneration that presented with CH of recent onset.
Thirteen patients completed the study. The mean corneal thickness before treatment was 1,310 (Equation is included in full-text article.)556 μm, which significantly reduced to 660 ± 148 μm at week 1 postoperatively (P = 0.001). It took 11.5 ± 6.5 days for corneal edema to resolve with a minimum and maximum of 5 and 24 days, respectively. Corrected distance Snellen visual acuity (CDVA) significantly improved from 0.04 ± 0.03 before treatment to 0.08 ± 0.06 at week 1 (P = 0.035) and continued to improve through month 1 [(0.11 ± 0.05), P = 0.007] and month 3 [(0.15 ± 0.08), P = 0.002]. No patient needed re-treatment with gas injection, and no complication was detected during the follow-up period.
Combined intracameral gas injection and approximation sutures are probably effective and safe for the treatment of acute CH. This treatment results in rapid recovery with very rare complications.
评估房内注入六氟化硫联合全层角膜缝线在治疗急性角膜水肿（CH）中的疗效和安全性。
本研究为一项未对照的病例系列研究，纳入了近期发生 CH 的圆锥角膜（KC）、球形角膜（KG）和边缘性角膜变性患者。
13 例患者完成了研究。治疗前平均角膜厚度为 1310.556μm，术后第 1 周显著降低至 660±148μm（P=0.001）。角膜水肿消退时间为 11.5±6.5 天，最短为 5 天，最长为 24 天。治疗后第 1 周最佳矫正视力（BCVA）从治疗前的 0.04±0.03 提高至 0.08±0.06（P=0.035），1 个月时[0.11±0.05，P=0.007]和 3 个月时[0.15±0.08，P=0.002]持续提高。无一例患者需要再次行气体注入治疗，随访期间无并发症发生。
房内注入六氟化硫联合角膜缝线固定术可能对治疗急性 CH 有效且安全。这种治疗方法可迅速恢复视力，且并发症罕见。
