Lansberg M G, Woolfenden A R, Norbash A M, Smith D B, Albers G W
Standford Stroke Center, Stanford Univeristy Medical Center, Stanford, CA USA; Department of Neurology, University of Colorado Health Sciences Center, Denver, CO USA; Colorado Neurological Institute, Englewood, CO, USA.
J Stroke Cerebrovasc Dis. 1999 Jan-Feb;8(1):42-4. doi: 10.1016/s1052-3057(99)80039-1.
Headache with neurological deficits and cerebrospinal fluid (CSF) lymphocytosis (HaNDL) is a benign condition with a transient ischemic attack (TIA)-like presentation. It is a disease of young adults that is characterized by headache, transient focal neurological symptoms, and lymphocytic pleocytosis. The onset of neurological symptoms after cerebral angiography in patients with this disease has occasionally been reported. The authors present the case of a 28-year-old man with episodes of left-sided numbness and weakness associated with headache. He underwent cerebral angiography as part of his evaluation, after which he experienced an episode of right hemiplegia and aphasia. A subsequent magnetic resonance image (MRI) revealed two small new infarcts in the left parietal cortex. A diagnosis of HaNDL was made based mainly on clinical symptoms and CSF analysis. The symptoms resolved with conservative therapy. HaNDL is a benign condition that can present with symptoms similar to a TIA. Although HaNDL remains a diagnosis of exclusion, caution is required when considering cerebral angiography in the evaluation of patients with a HaNDL-like syndrome, because these patients seem prone to developing neurological symptoms after angiography.
伴有神经功能缺损和脑脊液（CSF）淋巴细胞增多的头痛（HaNDL）是一种具有短暂性脑缺血发作（TIA）样表现的良性疾病。它是一种多见于年轻人的疾病，其特征为头痛、短暂性局灶性神经症状和淋巴细胞性细胞增多。本病患者在脑血管造影后出现神经症状的情况偶有报道。作者报告了一例28岁男性病例，其出现与头痛相关的左侧麻木和无力发作。作为评估的一部分，他接受了脑血管造影，之后出现了一次右侧偏瘫和失语发作。随后的磁共振成像（MRI）显示左侧顶叶皮质有两个新的小梗死灶。主要基于临床症状和脑脊液分析做出了HaNDL的诊断。症状经保守治疗后缓解。HaNDL是一种良性疾病，可表现出与TIA相似的症状。尽管HaNDL仍然是一种排除性诊断，但在评估具有HaNDL样综合征的患者时考虑进行脑血管造影时需要谨慎，因为这些患者在血管造影后似乎易于出现神经症状。
