Kwok S-K, Seo S-H, Ju J H, Park K-S, Yoon C-H, Kim W-U, Min J-K, Park S-H, Cho C-S, Kim H-Y
Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, South Korea.
Lupus. 2007;16(10):803-9. doi: 10.1177/0961203307082383.
The study was undertaken to evaluate clinical and laboratory characteristics of patients with lupus enteritis and to investigate its association with anti-endothelial cell antibodies (AECAs). Systemic lupus erythematosus (SLE) patients who were admitted to Kangnam St. Mary's Hospital with complaints of acute abdominal pain from January 1990 to July 2006 were reviewed retrospectively. The clinical features, laboratory data and prognosis of these patients were analyzed. Among the 706 SLE patients admitted during the study period, 87 were found to admit for acute abdominal pain. Among them, 41 patients were identified with lupus enteritis. The SLE disease activity index score at admission and the mean prednisolone dose administered during the last three months prior to admission were significantly higher in patients with lupus enteritis than those with other causes (P < 0.001, P = 0.036). Serum anti-endothelial cell antibody (AECA-IgG) titer was also significantly higher in patients with lupus enteritis than those with other manifestations or healthy controls (P = 0.040, P < 0.001). Four out of 13 recurrent patients had pre-existing anti-phospholipid syndrome (APS), whereas only one out of 28 non-recurrent patients had pre-existing APS (P = 0.028). Most of the patients with lupus enteritis showed good response to high-dose intravenous steroids and there was no death directly associated with lupus enteritis.
本研究旨在评估狼疮性肠炎患者的临床和实验室特征，并探讨其与抗内皮细胞抗体（AECAs）的关联。对1990年1月至2006年7月因急性腹痛入住江南圣母医院的系统性红斑狼疮（SLE）患者进行回顾性分析。分析这些患者的临床特征、实验室数据和预后。在研究期间收治的706例SLE患者中，87例因急性腹痛入院。其中，41例被确诊为狼疮性肠炎。狼疮性肠炎患者入院时的SLE疾病活动指数评分及入院前三个月平均给予的泼尼松龙剂量显著高于其他病因患者（P < 0.001，P = 0.036）。狼疮性肠炎患者的血清抗内皮细胞抗体（AECA-IgG）滴度也显著高于其他表现患者或健康对照（P = 0.040，P < 0.001）。13例复发患者中有4例既往有抗磷脂综合征（APS），而28例未复发患者中只有1例既往有APS（P = 0.028）。大多数狼疮性肠炎患者对大剂量静脉注射类固醇反应良好，且没有直接与狼疮性肠炎相关的死亡病例。
