• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
PfEMP1-DBL1alpha amino acid motifs in severe disease states of Plasmodium falciparum malaria.恶性疟原虫疟疾严重疾病状态下的PfEMP1-DBL1α氨基酸基序
Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15835-40. doi: 10.1073/pnas.0610485104. Epub 2007 Sep 25.
2
Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes.与儿童重症疟疾相关的恶性疟原虫优先表达由A组var基因编码的PfEMP1。
J Exp Med. 2004 May 3;199(9):1179-90. doi: 10.1084/jem.20040274.
3
Identification of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) as the rosetting ligand of the malaria parasite P. falciparum.恶性疟原虫红细胞膜蛋白1（PfEMP1）作为恶性疟原虫疟疾寄生虫的玫瑰花结配体的鉴定。
J Exp Med. 1998 Jan 5;187(1):15-23. doi: 10.1084/jem.187.1.15.
4
Diversity of the var gene family of Indonesian Plasmodium falciparum isolates.印度尼西亚疟原虫分离株 var 基因家族的多样性。
Malar J. 2013 Feb 27;12:80. doi: 10.1186/1475-2875-12-80.
5
B-cell epitopes in NTS-DBL1α of PfEMP1 recognized by human antibodies in Rosetting Plasmodium falciparum.恶性疟原虫红细胞凝集反应中人类抗体识别的PfEMP1的NTS-DBL1α中的B细胞表位。
PLoS One. 2014 Dec 1;9(12):e113248. doi: 10.1371/journal.pone.0113248. eCollection 2014.
6
A systematic review on genetic diversity of var gene DBL1α domain from different geographical regions in Plasmodium falciparum isolates.系统评价不同地理来源地区恶性疟原虫分离株 VAR 基因 DBL1α 区的遗传多样性。
Infect Genet Evol. 2021 Nov;95:105049. doi: 10.1016/j.meegid.2021.105049. Epub 2021 Aug 24.
7
Genetic diversity of expressed Plasmodium falciparum var genes from Tanzanian children with severe malaria.来自坦桑尼亚重症疟疾儿童的表达疟原虫 var 基因的遗传多样性。
Malar J. 2012 Jul 16;11:230. doi: 10.1186/1475-2875-11-230.
8
Sequence variation of PfEMP1-DBLalpha in association with rosette formation in Plasmodium falciparum isolates causing severe and uncomplicated malaria.恶性疟原虫分离株中与玫瑰花结形成相关的PfEMP1-DBLα序列变异，这些分离株导致严重和非复杂性疟疾。
Malar J. 2009 Aug 4;8:184. doi: 10.1186/1475-2875-8-184.
9
PfEMP1 - A Parasite Protein Family of Key Importance in Plasmodium falciparum Malaria Immunity and Pathogenesis.恶性疟原虫红细胞膜表面蛋白1——在恶性疟原虫疟疾免疫和发病机制中起关键作用的寄生虫蛋白家族。
Adv Parasitol. 2015 Apr;88:51-84. doi: 10.1016/bs.apar.2015.02.004. Epub 2015 Mar 23.
10
Structural basis for the ABO blood-group dependence of Plasmodium falciparum rosetting.裂殖疟原虫环型形成依赖 ABO 血型的结构基础。
PLoS Pathog. 2012;8(7):e1002781. doi: 10.1371/journal.ppat.1002781. Epub 2012 Jul 12.

引用本文的文献

1
Malaria: past, present, and future.疟疾：过去、现在与未来。
Signal Transduct Target Ther. 2025 Jun 17;10(1):188. doi: 10.1038/s41392-025-02246-3.
2
Proteomic Identification and Functional Analysis of Reveals Heparin-Binding Proteins.蛋白质组学鉴定及功能分析揭示肝素结合蛋白
J Trop Med. 2025 Jan 11;2025:8821002. doi: 10.1155/jotm/8821002. eCollection 2025.
3
Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype.鉴定含有结构域盒11、15和8的新型恶性疟原虫红细胞膜蛋白1（PfEMP1）变体，这些变体介导恶性疟原虫毒力相关的红细胞凝聚表型。
PLoS Pathog. 2025 Jan 13;21(1):e1012434. doi: 10.1371/journal.ppat.1012434. eCollection 2025 Jan.
4
Genotyping Gene DBL1α Domain of Severe and Non-severe Patients.重症和非重症患者基因DBL1α结构域的基因分型
Indian J Microbiol. 2024 Jun;64(2):583-592. doi: 10.1007/s12088-024-01200-1. Epub 2024 Feb 6.
5
Measuring changes in census population size in response to sequential malaria control interventions.衡量人口普查人口规模对一系列疟疾控制干预措施的反应变化。
medRxiv. 2024 Jul 31:2023.05.18.23290210. doi: 10.1101/2023.05.18.23290210.
6
Neutral vs. non-neutral genetic footprints of Plasmodium falciparum multiclonal infections.疟原虫多克隆感染的中性与非中性遗传痕迹。
PLoS Comput Biol. 2023 Jan 3;19(1):e1010816. doi: 10.1371/journal.pcbi.1010816. eCollection 2023 Jan.
7
Bayesian estimation of community size and overlap from random subsamples.贝叶斯估计群落大小和重叠的随机抽样。
PLoS Comput Biol. 2022 Sep 19;18(9):e1010451. doi: 10.1371/journal.pcbi.1010451. eCollection 2022 Sep.
8
Aptamers as a novel diagnostic and therapeutic tool and their potential use in parasitology.适配体作为一种新型诊断和治疗工具及其在寄生虫学中的潜在应用。
Biomedica. 2020 May 1;40(Supl. 1):148-165. doi: 10.7705/biomedica.4765.
9
Exploring Gene Expression to Assess Host Selection Pressure on Parasites During Infancy.探索基因表达，评估婴儿期寄生虫对宿主的选择压力。
Front Immunol. 2019 Oct 9;10:2328. doi: 10.3389/fimmu.2019.02328. eCollection 2019.
10
Bayes-optimal estimation of overlap between populations of fixed size.大小固定的群体间重叠的贝叶斯最优估计。
PLoS Comput Biol. 2019 Mar 29;15(3):e1006898. doi: 10.1371/journal.pcbi.1006898. eCollection 2019 Mar.

本文引用的文献

1
Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestration.参与恶性疟原虫胎盘滞留的VAR2CSA DBL3X的表位作图与拓扑分析。
PLoS Pathog. 2006 Nov;2(11):e124. doi: 10.1371/journal.ppat.0020124.
2
Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia.与高疟原虫血症患者相比，脑型疟患者恶性疟原虫分离株中var基因的差异转录。
Mol Biochem Parasitol. 2006 Dec;150(2):211-8. doi: 10.1016/j.molbiopara.2006.08.005. Epub 2006 Sep 5.
3
Differential expression of var gene groups is associated with morbidity caused by Plasmodium falciparum infection in Tanzanian children.var基因群组的差异表达与坦桑尼亚儿童因恶性疟原虫感染引起的发病率相关。
Infect Immun. 2006 Jul;74(7):3904-11. doi: 10.1128/IAI.02073-05.
4
Virulence of malaria is associated with differential expression of Plasmodium falciparum var gene subgroups in a case-control study.在一项病例对照研究中，疟疾的毒力与恶性疟原虫var基因亚组的差异表达有关。
J Infect Dis. 2006 Jun 1;193(11):1567-74. doi: 10.1086/503776. Epub 2006 Apr 20.
5
Structural basis for Duffy recognition by the malaria parasite Duffy-binding-like domain.疟原虫达菲结合样结构域识别达菲的结构基础。
Nature. 2006 Feb 9;439(7077):741-4. doi: 10.1038/nature04443. Epub 2005 Dec 21.
6
Plasmodium falciparum variant surface antigen expression patterns during malaria.疟疾期间恶性疟原虫变异表面抗原的表达模式
PLoS Pathog. 2005 Nov;1(3):e26. doi: 10.1371/journal.ppat.0010026. Epub 2005 Nov 18.
7
Further definition of PfEMP-1 DBL-1alpha domains mediating rosetting adhesion of Plasmodium falciparum.介导恶性疟原虫玫瑰花结黏附的疟原虫红细胞膜蛋白-1（PfEMP-1）DBL-1α结构域的进一步定义。
Mol Biochem Parasitol. 2005 Nov;144(1):109-13. doi: 10.1016/j.molbiopara.2005.06.009.
8
Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum.恶性疟原虫EBA-175红细胞入侵途径的结构基础
Cell. 2005 Jul 29;122(2):183-93. doi: 10.1016/j.cell.2005.05.033.
9
Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda.青蒿素与非青蒿素联合疗法治疗单纯性疟疾：来自乌干达四个地点的随机临床试验
PLoS Med. 2005 Jul;2(7):e190. doi: 10.1371/journal.pmed.0020190. Epub 2005 Jul 26.
10
Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria.携带血红蛋白C的红细胞上PfEMP-1的异常表达可能预防疟疾。
Nature. 2005 Jun 23;435(7045):1117-21. doi: 10.1038/nature03631.

恶性疟原虫疟疾严重疾病状态下的PfEMP1-DBL1α氨基酸基序

PfEMP1-DBL1alpha amino acid motifs in severe disease states of Plasmodium falciparum malaria.

作者信息

Normark Johan, Nilsson Daniel, Ribacke Ulf, Winter Gerhard, Moll Kirsten, Wheelock Craig E, Bayarugaba Justus, Kironde Fred, Egwang Thomas G, Chen Qijun, Andersson Björn, Wahlgren Mats

机构信息

Department of Microbiology and Tumor and Cell Biology (MTC), Karolinska Institutet and Swedish Institute for Infectious Diseases Control (SMI), Box 280, Nobels väg 16, SE-17177 Stockholm, Sweden.

出版信息

Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15835-40. doi: 10.1073/pnas.0610485104. Epub 2007 Sep 25.

DOI:10.1073/pnas.0610485104
PMID:17895392
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1994139/
Abstract

An infection with Plasmodium falciparum may lead to severe malaria as a result of excessive binding of infected erythrocytes in the microvasculature. Vascular adhesion is mediated by P. falciparum erythrocyte membrane protein-1 (PfEMP1), which is encoded for by highly polymorphic members of the var-gene family. Here, we profile var gene transcription in fresh P. falciparum trophozoites from Ugandan children with malaria through var-specific DBL1alpha-PCR amplification and sequencing. A method for subsectioning region alignments into homology areas (MOTIFF) was developed to examine collected sequences. Specific PfEMP1-DBL1alpha amino acid motifs correlated with rosetting and severe malaria, with motif location corresponding to distinct regions of receptor interaction. The method is potentially applicable to other families of variant proteins and may be useful in identifying sequence-phenotype relationships. The results suggest that certain PfEMP1 sequences are predisposed to inducing severe malaria.

摘要

恶性疟原虫感染可能会由于感染的红细胞在微血管中过度黏附而导致严重疟疾。血管黏附由恶性疟原虫红细胞膜蛋白1（PfEMP1）介导，该蛋白由var基因家族的高度多态性成员编码。在此，我们通过var特异性DBL1α-PCR扩增和测序，分析了来自乌干达患疟疾儿童的新鲜恶性疟原虫滋养体中的var基因转录情况。我们开发了一种将区域比对细分为同源区域（MOTIFF）的方法来检查收集到的序列。特定的PfEMP1-DBL1α氨基酸基序与红细胞凝聚和严重疟疾相关，基序位置对应于受体相互作用的不同区域。该方法可能适用于其他变体蛋白家族，并且可能有助于识别序列-表型关系。结果表明，某些PfEMP1序列易于诱发严重疟疾。